Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Sufentanil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 known ✓ | P35372 | 4/20 | 0.85 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.85 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.85 |
| ▸ | OPRD1 | P41143 | 3/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Sufentanil SCHEMBL192322 | 1.00 | OPRM1 (0.85) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Sufentanil SCHEMBL6057143 | 1.00 | OPRM1 (0.85) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Sufentanil SCHEMBL26728 | 0.92 | OPRM1 (1.00) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Sufentanil SCHEMBL27722103 | 0.92 | OPRM1 (1.00) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Sufentanil SCHEMBL28438312 | 0.92 | OPRM1 (0.98) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Sufentanil SCHEMBL780198 | 0.92 | OPRM1 (0.98) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Sufentanil SCHEMBL28432948 | 0.92 | OPRM1 (0.98) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Sufentanil SCHEMBL2727222 | 0.91 | OPRM1 (0.96) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Citric Acid SCHEMBL28501611 | 0.89 | OPRM1 (0.67) | OPRM1SLC22A1ABCB1OPRD1OPRK1 | |
| Sufentanil SCHEMBL28429544 | 0.88 | OPRM1 (0.91) | OPRM1SLC22A1ABCB1OPRD1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2383 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| EP-4688415-A1 | DOUBLE LAYER TUBING FOR IV INFUSION SETS | CareFusion 303, Inc. (US) | 2026-02-11 | — | — | EP | claimed |
| US-12508253-B2 | Pediatric combination | Cessatech A/S (DK) | 2025-12-30 | — | — | US | claimed |
| US-20250368630-A1 | PREPARATION OF SUFENTANIL CITRATE AND SUFENTANIL BASE | GOLDMAN SACHS BANK USA, AS ADMINISTRATIVE AGENT | 2025-12-04 | — | — | US | claimed |
| EP-4417405-B1 | PLASTIC LENS ELEMENT, OPTICAL IMAGING MODULE AND ELECTRONIC DEVICE | LARGAN PRECISION CO LTD (TW) | 2025-10-01 | — | — | EP | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-12371423-B2 | Preparation of sufentanil citrate and sufentanil base | SpecGx LLC (US) | 2025-07-29 | — | — | US | claimed |
| US-20250205278-A1 | METHODS AND COMPOSITIONS FOR WOUND HEALING | ABBOTT NICHOLAS L (US) | 2025-06-26 | — | — | US | claimed |
| US-20250189547-A1 | SURFACE-ENHANCED RAMAN NANOPARTICLE AND DETECTION METHOD FOR FENTANYLS | Shenzhen Customs Industrial Products Testing Technology Center (CN) | 2025-06-12 | — | — | US | claimed |
| WO-2025111413-A1 | TREATMENT FOR SKIN DISORDERS | Mycotechnology, Inc. (US) | 2025-05-30 | — | — | WO | claimed |
| CN-101141951-A | Sublingual coated tablet | ETHYPHARM SA (FR) | 2008-03-12 | — | — | CN | claimed |
| WO-2008008120-A1 | SOLID FORM | FMC CORPORATION (US) | 2008-01-17 | — | — | WO | claimed |
| US-20080014228-A1 | Solid form | FMC CORPORATION | 2008-01-17 | — | — | US | claimed |
| WO-2007141328-A1 | LOW DOSE SUBLINGUAL TABLETS OF OPIOID ANALGESICS AND PREPARATION PROCESS | ETHYPHARM (FR) | 2007-12-13 | — | — | WO | claimed |
| US-20070286900-A1 | LOW DOSE TABLETS OF OPIOID ANALGESICS AND PREPARATION PROCESS | ETHYPHARM (FR) | 2007-12-13 | — | — | US | claimed |
| EP-1858491-A1 | SUBLINGUAL COATED TABLET | ETHYPHARM (FR) | 2007-11-28 | — | — | EP | claimed |
| US-20060210632-A1 | Sublingual coated tablet of fentanyl | ETHYPHARM (FR) | 2006-09-21 | — | — | US | claimed |
| WO-2006097361-A1 | SUBLINGUAL COATED TABLET | ETHYPHARM (FR) | 2006-09-21 | — | — | WO | claimed |
| EP-0910432-B1 | ENHANCED ELECTROTRANSPORT OF THERAPEUTIC AGENTS HAVING POLYBASIC ANIONIC COUNTER-IONS | ALZA CORP (US) | 2003-10-01 | — | — | EP | claimed |
| US-20030176421-A1 | PROKINETIC AGENTS FOR TREATING GASTRIC HYPOMOTILITY AND RELATED DISORDERS | WATSON JOHN W (US) | 2003-09-18 | — | — | US | claimed |