Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 8/20 | 0.57 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | CNR1 | P21554 | 10/20 | 0.40 |
| ▸ | CNR2 | P34972 | 10/20 | 0.40 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17965436 | 0.95 | SIGMAR1 (0.62) | SIGMAR1ABL1CNR1CNR2KCNH2 | |
| SCHEMBL17965435 | 0.82 | SIGMAR1 (0.66) | SIGMAR1ABL1CNR1CNR2KCNH2 | |
| Oxalic Acid SCHEMBL4122952 | 0.82 | SIGMAR1 (0.54) | SIGMAR1ABL1CNR1CNR2KCNH2 | |
| Oxalic Acid SCHEMBL1356546 | 0.81 | SIGMAR1 (0.87) | SIGMAR1ABL1KCNH2KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL1357082 | 0.81 | SIGMAR1 (0.87) | SIGMAR1ABL1KCNH2KDM4EALDH1A1 | |
| Oxalic Acid SCHEMBL1356828 | 0.76 | SIGMAR1 (0.71) | SIGMAR1ABL1KCNH2KDM4EALDH1A1 | |
| SCHEMBL1356874 | 0.74 | SIGMAR1 (0.60) | SIGMAR1ABL1CNR1CNR2KCNH2 | |
| SCHEMBL1356691 | 0.73 | SIGMAR1 (1.00) | SIGMAR1KCNH2 | |
| SCHEMBL1354724 | 0.73 | SIGMAR1 (1.00) | SIGMAR1KCNH2 | |
| SCHEMBL1356873 | 0.73 | SIGMAR1 (0.77) | SIGMAR1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1994008-B1 | IMIDAZOLE COMPOUNDS HAVING PHARMACEUTICAL ACTIVITY TOWARDS THE SIGMA RECEPTOR | ESTEVE LABOR DR (ES) | 2016-08-10 | — | — | EP | disclosed |
| US-8410159-B2 | Imidazole compounds having pharmaceutical activity towards the sigma receptor | LABORATORIES DEL DR. ESTEVE, S.A. (ES) | 2013-04-02 | — | — | US | disclosed |
| US-20090137560-A1 | IMIDAZOLE COMPOUNDS HAVING PHARMACEUTICAL ACTIVITY TOWARDS THE SIGMA RECEPTOR | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2009-05-28 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090137560-A1 | IMIDAZOLE COMPOUNDS HAVING PHARMACEUTICAL ACTIVITY TOWARDS THE SIGMA RECEPTOR | SIGMAR1, TMEM97, OPRK1 | SIGMAR1 1/4885ABL1 452/4885CNR1 38/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.