Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 16/20 | 0.92 |
| ▸ | IGF1R | P08069 | 6/20 | 0.77 |
| ▸ | SRC | P12931 | 2/20 | 0.69 |
| ▸ | IKBKB | O14920 | 1/20 | 0.69 |
| ▸ | EGFR | P00533 | 1/20 | 0.69 |
| ▸ | LYN | P07948 | 1/20 | 0.69 |
| ▸ | BRAF | P15056 | 1/20 | 0.69 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.69 |
| ▸ | KDR | P35968 | 1/20 | 0.69 |
| ▸ | PRKCQ | Q04759 | 1/20 | 0.69 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.69 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.69 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4122991 | 1.00 | MAP2K1 (0.92) | MAP2K1IGF1RSRCIKBKBEGFR | |
| SCHEMBL4123948 | 0.96 | MAP2K1 (1.00) | MAP2K1IGF1RSRCIKBKBEGFR | |
| SCHEMBL4123952 | 0.96 | MAP2K1 (1.00) | MAP2K1IGF1RSRCIKBKBEGFR | |
| SCHEMBL4129826 | 0.92 | MAP2K1 (1.00) | MAP2K1IGF1RSRCIKBKBEGFR | |
| SCHEMBL4129821 | 0.92 | MAP2K1 (1.00) | MAP2K1IGF1RSRCIKBKBEGFR | |
| SCHEMBL4101166 | 0.91 | MAP2K1 (1.00) | MAP2K1IGF1RSRCIKBKBEGFR | |
| SCHEMBL4101167 | 0.91 | MAP2K1 (1.00) | MAP2K1IGF1RSRCIKBKBEGFR | |
| SCHEMBL4127203 | 0.90 | MAP2K1 (0.88) | MAP2K1IGF1REGFRMAPK3MAPK1 | |
| SCHEMBL4127200 | 0.90 | MAP2K1 (0.88) | MAP2K1IGF1REGFRMAPK3MAPK1 | |
| SCHEMBL4122589 | 0.89 | MAP2K1 (1.00) | MAP2K1IGF1RSRCIKBKBEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090099356-A1 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION | WYETH (US) | 2009-04-16 | — | — | US | claimed |
| EP-1981505-A4 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION | WYETH CORP (US) | 2009-05-13 | — | — | EP | disclosed |
| US-20090099356-A1 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION | WYETH (US) | 2009-04-16 | — | — | US | disclosed |
| EP-1981505-A2 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION | Wyeth a Corporation of the State of Delaware (US) | 2008-10-22 | — | — | EP | disclosed |
| WO-2007092153-A2 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION | WYETH (US) | 2007-08-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090099356-A1 | PREPARATION OF 7-ALKENYL-3 QUINOLINECARBONITRILES VIA A PALLADIUM MEDIATED COUPLING REACTION | PARK7, UQCRB, PRMT7 | MAP2K1 2266/4885IGF1R 2125/4885SRC 3605/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.