Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 3/20 | 0.48 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | MAPK8 | P45983 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | UGCG | Q16739 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.38 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13696799 | 0.90 | USP30 (0.49) | SLC6A2SLC6A4KCNH2CYP2D6TDP1 | |
| SCHEMBL4120622 | 0.85 | SLC6A2 (0.66) | SLC6A2SLC6A4KCNH2CYP2D6ALDH1A1 | |
| SCHEMBL13696812 | 0.81 | SLC6A2 (0.74) | SLC6A2SLC6A4KCNH2CYP2D6SLC6A3 | |
| SCHEMBL4112677 | 0.81 | SLC6A2 (0.74) | SLC6A2SLC6A4KCNH2CYP2D6SLC6A3 | |
| SCHEMBL4508193 | 0.77 | SLC6A2 (0.53) | SLC6A2SLC6A4KCNH2CYP2D6ALDH1A1 | |
| SCHEMBL5909239 | 0.76 | POLB (0.52) | TDP1MAPK8ALDH1A1POLBUGCG | |
| SCHEMBL4282426 | 0.76 | SLC6A2 (0.46) | SLC6A2SLC6A4KCNH2CYP2D6ALDH1A1 | |
| SCHEMBL4635761 | 0.75 | SLC6A2 (0.62) | SLC6A2SLC6A4KCNH2CYP2D6SLC6A3 | |
| SCHEMBL13696790 | 0.75 | SLC6A2 (0.59) | SLC6A2SLC6A4KCNH2CYP2D6ALDH1A1 | |
| SCHEMBL4105025 | 0.74 | SLC6A2 (0.64) | SLC6A2SLC6A4KCNH2CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090239928-A1 | N-Pyrrolidin-3YL-Amide Derivatives As Serotonin and Noradrenalin Re-Uptake Inhibitors | PFIZER INC. | 2009-09-24 | — | — | US | disclosed |
| EP-1828121-A2 | N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALIN RE-UPTAKE INHIBITORS | Pfizer Limited (GB) | 2007-09-05 | — | — | EP | disclosed |
| WO-2006064336-A2 | N-PYRROLIDIN-3-YL-AMIDE DERIVATIVES AS SEROTONIN AND NORADRENALIN RE-UPTAKE INHIBITORS | PFIZER LIMITED (GB) | 2006-06-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090239928-A1 | N-Pyrrolidin-3YL-Amide Derivatives As Serotonin and Noradrenalin Re-Uptake Inhibitors | AOC3, AOC2, TPH2 | SLC6A2 5/4885SLC6A4 36/4885KCNH2 2694/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.