Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 9/20 | 0.77 |
| ▸ | MAPT | P10636 | 10/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.69 |
| ▸ | POLB | P06746 | 2/20 | 0.63 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 3/20 | 0.57 |
| ▸ | GAA | P10253 | 2/20 | 0.57 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.56 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2482386 | 0.87 | HTR6 (1.00) | HTR6MAPTALDH1A1POLBNPSR1 | |
| SCHEMBL3919058 | 0.87 | HTR6 (0.73) | HTR6MAPTALDH1A1POLBNPSR1 | |
| Hydrochloric Acid SCHEMBL5398700 | 0.86 | HTR6 (0.71) | HTR6MAPTALDH1A1POLBNPSR1 | |
| SCHEMBL2482705 | 0.83 | HTR6 (0.70) | HTR6MAPTALDH1A1POLBNPSR1 | |
| SCHEMBL5273517 | 0.82 | HTR6 (0.79) | HTR6MAPTALDH1A1POLBNPSR1 | |
| SCHEMBL3616361 | 0.82 | MAPT (1.00) | HTR6MAPTALDH1A1POLBNPSR1 | |
| SCHEMBL5271559 | 0.80 | ALDH1A1 (0.58) | HTR6MAPTALDH1A1HTTCYP1A2 | |
| SCHEMBL1844704 | 0.78 | HTR6 (1.00) | HTR6MAPTALDH1A1POLBNPSR1 | |
| SCHEMBL475881 | 0.77 | SMN1; SMN2 (0.78) | HTR6MAPTALDH1A1POLBNPSR1 | |
| SCHEMBL2482987 | 0.77 | MAPT (1.00) | HTR6MAPTALDH1A1POLBNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2037925-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | Epix Delaware, Inc. (US) | 2009-03-25 | — | — | EP | disclosed |
| WO-2008002539-A1 | COMBINATIONS COMPRISING 5HT6 MODULATORS AND CHOLINESTERASE INHIBITORS | EPIX DELAWARE, INC. (US) | 2008-01-03 | — | — | WO | disclosed |