Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.51 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.51 |
| ▸ | CXCR2 | P25025 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 2/20 | 0.41 |
| ▸ | WDR5 | P61964 | 1/20 | 0.40 |
| ▸ | KCNQ4 | P56696 | 1/20 | 0.40 |
| ▸ | KCNQ5 | Q9NR82 | 1/20 | 0.40 |
| ▸ | KCNMA1 | Q12791 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31122314 | 1.00 | HSP90AA1 (0.51) | HSP90AA1HSP90AB1CXCR2MEN1KMT2A | |
| SCHEMBL31458629 | 0.88 | KCNMA1 (0.54) | HSP90AA1HSP90AB1MEN1KMT2AGAA | |
| SCHEMBL3327166 | 0.88 | KCNMA1 (0.54) | HSP90AA1HSP90AB1MEN1KMT2AGAA | |
| SCHEMBL3787046 | 0.87 | KMT2A (0.54) | HSP90AA1HSP90AB1MEN1KMT2APDK1 | |
| SCHEMBL6628806 | 0.86 | PDK1 (0.56) | HSP90AA1HSP90AB1MEN1KMT2APDK1 | |
| SCHEMBL5731619 | 0.84 | POLB (0.54) | HSP90AA1HSP90AB1MEN1KMT2AGAA | |
| SCHEMBL2391319 | 0.84 | CXCR2 (0.53) | CXCR2MEN1KMT2AGAANPC1 | |
| SCHEMBL23954504 | 0.83 | KMT2A (0.47) | HSP90AA1HSP90AB1MEN1KMT2APDK1 | |
| SCHEMBL551648 | 0.83 | HDAC1 (0.50) | HSP90AA1HSP90AB1MEN1KMT2APDK1 | |
| SCHEMBL12225275 | 0.83 | HSP90AA1 (0.45) | HSP90AA1HSP90AB1MEN1KMT2APDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | HSP90AA1 4018/4885HSP90AB1 3883/4885CXCR2 1885/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.