Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.35 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | HTR2C | P28335 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.34 |
| ▸ | TUBB4A | P04350 | 2/20 | 0.34 |
| ▸ | TUBB | P07437 | 2/20 | 0.34 |
| ▸ | TUBA3C | P0DPH7 | 2/20 | 0.34 |
| ▸ | TUBA1B | P68363 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4124313 | 1.00 | KDM4E (0.37) | KDM4ECYP3A4NFE2L2HCRTR1HCRTR2 | |
| SCHEMBL13775493 | 0.89 | L3MBTL1 (0.37) | KDM4ECYP3A4HCRTR1HCRTR2TP53 | |
| SCHEMBL4112572 | 0.89 | HCRTR1 (0.37) | KDM4EHCRTR1HCRTR2ALDH1A1HPGD | |
| SCHEMBL4110971 | 0.82 | KMT2A (0.33) | KDM4EHCRTR1HCRTR2ALDH1A1HSD17B10 | |
| SCHEMBL4122700 | 0.79 | NFE2L2 (0.38) | KDM4ENFE2L2ALDH1A1HTR1AHPGD | |
| SCHEMBL4122696 | 0.79 | NFE2L2 (0.38) | KDM4ENFE2L2ALDH1A1HTR1AHPGD | |
| SCHEMBL4124239 | 0.78 | HCRTR1 (0.38) | KDM4EHCRTR1HCRTR2ALDH1A1HPGD | |
| SCHEMBL4111361 | 0.77 | HCRTR1 (0.38) | KDM4EHCRTR1HCRTR2ALDH1A1HPGD | |
| SCHEMBL4118412 | 0.76 | HPGD (0.41) | KDM4EHCRTR1HCRTR2ALDH1A1HPGD | |
| SCHEMBL13775802 | 0.75 | KMT2A (0.40) | KDM4EHCRTR1HCRTR2TP53ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | KDM4E 2123/4885CYP3A4 1692/4885NFE2L2 2491/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.