Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NCEH1 | Q6PIU2 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | METAP2 | P50579 | 1/20 | 0.41 |
| ▸ | METAP1 | P53582 | 1/20 | 0.41 |
| ▸ | MAOB | P27338 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3370074 | 0.82 | HSD17B10 (0.59) | ALDH1A1HPGDMAPTHSD17B10KDM4E | |
| SCHEMBL4960213 | 0.79 | NCEH1 (0.42) | NCEH1ALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL7300345 | 0.78 | NCEH1 (0.53) | NCEH1ALDH1A1HPGDMAPTPKM | |
| SCHEMBL30714893 | 0.78 | ABCG2 (0.54) | NCEH1ALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL975681 | 0.78 | NCEH1 (0.53) | NCEH1ALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL16869403 | 0.78 | NCEH1 (0.53) | NCEH1ALDH1A1HPGDMAPTPKM | |
| SCHEMBL426582 | 0.78 | ABCG2 (0.54) | NCEH1ALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL4835012 | 0.78 | NCEH1 (0.53) | NCEH1ALDH1A1HPGDMAPTPKM | |
| SCHEMBL23391023 | 0.77 | NCEH1 (0.51) | NCEH1ALDH1A1HPGDMAPTHSD17B10 | |
| SCHEMBL1392829 | 0.77 | NCEH1 (0.51) | NCEH1ALDH1A1HPGDMAPTPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090081165-A1 | BICYCLIC HETEROARYL DERIVATIVES | GENELABS TECHNOLOGIES, INC. | 2009-03-26 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090081165-A1 | BICYCLIC HETEROARYL DERIVATIVES | HAVCR2, MAVS, ZC3HAV1 | NCEH1 2450/4885ALDH1A1 2299/4885HPGD 3746/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.