Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 3/20 | 0.57 |
| ▸ | ACHE | P22303 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | CA12 | O43570 | 6/20 | 0.50 |
| ▸ | CA1 | P00915 | 6/20 | 0.50 |
| ▸ | CA2 | P00918 | 6/20 | 0.50 |
| ▸ | CA7 | P43166 | 6/20 | 0.50 |
| ▸ | CA9 | Q16790 | 6/20 | 0.50 |
| ▸ | CA14 | Q9ULX7 | 6/20 | 0.50 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | XDH | P47989 | 2/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | GFER | P55789 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | FUT7 | Q11130 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17926269 | 0.91 | CYP3A4 (0.58) | CYP3A4ACHEHPGDCA12CA1 | |
| SCHEMBL2662948 | 0.86 | CYP3A4 (0.62) | CYP3A4ACHEHPGDCA12CA1 | |
| SCHEMBL19677594 | 0.85 | CYP3A4 (0.56) | CYP3A4ACHEHPGDCA12CA1 | |
| SCHEMBL18176572 | 0.84 | CA12 (0.54) | CYP3A4ACHEHPGDCA12CA1 | |
| SCHEMBL12554417 | 0.83 | CYP3A4 (0.58) | CYP3A4ACHEHPGDCA12CA1 | |
| SCHEMBL20778162 | 0.81 | CA12 (0.61) | CYP3A4ACHEHPGDCA12CA1 | |
| SCHEMBL12553003 | 0.79 | CYP3A4 (0.59) | CYP3A4ACHEHPGDCA12CA1 | |
| SCHEMBL19944524 | 0.78 | CA12 (0.47) | CYP3A4ACHEHPGDCA12CA1 | |
| SCHEMBL198717 | 0.77 | KDM4E (0.65) | CYP3A4ACHEHPGDCA12CA1 | |
| SCHEMBL197898 | 0.77 | CYP3A4 (0.81) | CYP3A4ACHEHPGDCA12CA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8481519-B2 | Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the derivatives thereof for the treatment of benign prostatic hyperplasia, prostate carcinoma and spinobulbar muscular atrophy | LTS LOHMANN THERAPIE-SYSTEME AG (DE) | 2013-07-09 | — | — | US | disclosed |
| CN-101115488-B | Pharmaceutical use of atraric acid | LOHMANN THERAPIE SYST LTS | 2011-03-30 | — | — | CN | disclosed |
| US-20090143466-A1 | Isolation of Atraric Acid, Synthesis of Atraric Acid Derivatives, and Use of Atraric Acid and the Derivatives Thereof for the Treatment of Benign Prostatic Hyperplasia, Prostate Carcinoma and Spinobulbar Muscular Atrophy | LTS LOHMANN THERAPIE-SYSTEME AG (DE) | 2009-06-04 | — | — | US | disclosed |
| CN-101115488-A | Isolation of atraric acid, synthesis of atraric acid derivatives, and use of atraric acid and the deritives thereof for the treatment of benign prostate hyperplasia, prostate carcinoma and spinobulbar | LOHMANN THERAPIE SYST LTS (DE) | 2008-01-30 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090143466-A1 | Isolation of Atraric Acid, Synthesis of Atraric Acid Derivatives, and Use of Atraric Acid and the Derivatives Thereof for the Treatment of Benign Prostatic Hyperplasia, Prostate Carcinoma and Spinobulbar Muscular Atrophy | RARB, RARA, AR | CYP3A4 3211/4885ACHE 416/4885HPGD 270/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.