Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 4/20 | 0.38 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | KCNMA1 | Q12791 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | APP | P05067 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4119996 | 1.00 | LPAR1 (0.38) | LPAR1AMY1AHSP90AA1HSP90AB1CNR2 | |
| SCHEMBL4123994 | 1.00 | LPAR1 (0.38) | LPAR1AMY1AHSP90AA1HSP90AB1CNR2 | |
| SCHEMBL4122138 | 0.90 | TDP1 (0.42) | LPAR1CNR2KDM4EKCNMA1HIF1A | |
| SCHEMBL4127991 | 0.88 | ALDH1A1 (0.41) | LPAR1HSP90AA1HSP90AB1KCNMA1ALDH1A1 | |
| SCHEMBL4117720 | 0.88 | LPAR1 (0.38) | LPAR1HSP90AA1HSP90AB1CNR2ALDH1A1 | |
| SCHEMBL4125270 | 0.88 | LPAR1 (0.38) | LPAR1HSP90AA1HSP90AB1CNR2ALDH1A1 | |
| SCHEMBL4679921 | 0.88 | ALDH1A1 (0.43) | LPAR1HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL4118453 | 0.88 | AMY1A (0.38) | AMY1AHSP90AA1HSP90AB1ALDH1A1TDP1 | |
| SCHEMBL4111096 | 0.88 | ALDH1A1 (0.43) | LPAR1HSP90AA1HSP90AB1ALDH1A1MAPT | |
| SCHEMBL4109292 | 0.86 | MAPT (0.38) | LPAR1HSP90AA1HSP90AB1KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2009-07-16 | — | — | US | disclosed |
| EP-1939205-A1 | TRICYCLIC COMPOUND | Daiichi Sankyo Company, Limited (JP) | 2008-07-02 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181942-A1 | TRICYCLIC COMPOUNDS | FDFT1, COASY, HMGCR | LPAR1 345/4885AMY1A 2258/4885HSP90AA1 4018/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.