Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | RORC | P51449 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | LIG1 | P18858 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10739254 | 0.90 | TDP1 (0.54) | TDP1SMN1; SMN2POLBNPC1MAPT | |
| SCHEMBL7326428 | 0.89 | TDP1 (0.71) | TDP1SMN1; SMN2POLBNPC1MAPT | |
| SCHEMBL13596071 | 0.87 | MAPT (0.45) | TDP1SMN1; SMN2POLBNPC1MAPT | |
| SCHEMBL13637511 | 0.80 | TDP1 (0.62) | TDP1SMN1; SMN2POLBMAPTRAB9A | |
| SCHEMBL6121031 | 0.80 | FLT3 (0.47) | TDP1SMN1; SMN2POLBNPC1MAPT | |
| SCHEMBL7922185 | 0.79 | HTT (0.68) | TDP1SMN1; SMN2POLBNPC1MAPT | |
| SCHEMBL614170 | 0.79 | TDP1 (0.48) | TDP1SMN1; SMN2NPC1MAPTRAB9A | |
| SCHEMBL616188 | 0.78 | TDP1 (0.56) | TDP1SMN1; SMN2POLBNPC1MAPT | |
| SCHEMBL11821446 | 0.78 | GAA (0.62) | POLBNPC1MAPTRAB9AMEN1 | |
| SCHEMBL4126877 | 0.78 | FLT3 (0.46) | SMN1; SMN2POLBMAPTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-24 | — | — | US | disclosed |
| US-20090318690-A1 | Benzisoxazole Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-24 | — | — | US | disclosed |
| US-20090318690-A1 | Benzisoxazole Compound | EISAI R&D MANAGEMENT CO., LTD. (JP) | 2009-12-24 | — | — | US | disclosed |
| EP-2017275-A1 | BENZISOXAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2009-01-21 | — | — | EP | disclosed |
| EP-2017275-A1 | BENZISOXAZOLE COMPOUND | Eisai R&D Management Co., Ltd. (JP) | 2009-01-21 | — | — | EP | disclosed |
| US-4820819-A | 5-phenyl-3[2H]-pyridazinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-04-11 | — | — | US | disclosed |
| US-4678786-A | Pharmaceutical compositions having β-adrenoceptor antagonist activity employing pyridazinone derivatives | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1987-07-07 | — | — | US | disclosed |
| EP-0138344-A2 | Pyridazinones as beta-adrenoceptor antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1985-04-24 | — | — | EP | disclosed |
| US-4474787-A | 7,6 Dioxo-4H,6H-pyrano[3,2-g]quinoline dicarboxylic acids and anti-allergic use thereof | FISONS LIMITED (GB) | 1984-10-02 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090318690-A1 | Benzisoxazole Compound | NR1I2, NR1I3, NR0B1 | TDP1 4649/4885SMN1; SMN2 3331/4885POLB 3780/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.