Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.56 |
| ▸ | CDK1 | P06493 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | DRD1 | P21728 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP1 | P29466 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL616188 | 0.90 | TDP1 (0.56) | TDP1SMN1; SMN2FLT3POLBNPC1 | |
| SCHEMBL4125735 | 0.89 | TDP1 (0.56) | TDP1SMN1; SMN2FLT3RORCHTT | |
| SCHEMBL10739254 | 0.88 | TDP1 (0.54) | TDP1SMN1; SMN2FLT3RORCHTT | |
| Ethopabate SCHEMBL540932 | 0.83 | TDP1 (1.00) | TDP1SMN1; SMN2CDK1RORCPOLB | |
| Ethopabate SCHEMBL29625103 | 0.83 | TDP1 (1.00) | TDP1SMN1; SMN2CDK1RORCPOLB | |
| SCHEMBL8687307 | 0.83 | TDP1 (0.73) | TDP1SMN1; SMN2CDK1RORCHTT | |
| Ethopabate SCHEMBL28629644 | 0.82 | TDP1 (0.97) | TDP1SMN1; SMN2CDK1RORCPOLB | |
| SCHEMBL13924205 | 0.82 | FLT3 (0.55) | TDP1SMN1; SMN2FLT3POLBNPC1 | |
| SCHEMBL28427762 | 0.81 | TDP1 (0.80) | TDP1SMN1; SMN2CDK1RORCHTT | |
| SCHEMBL2374331 | 0.81 | HSP90AA1 (0.50) | TDP1FLT3HTTNPC1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006570-A | Dihydrobenzofuran- and chroman-carboxamide derivatives, processes for the preparation thereof and use thereof as neuroleptics | LABORATOIRES DELAGRANGE (FR) | 1991-04-09 | — | — | US | disclosed |
| US-4924010-A | GASTROINTESTINAL DISORDERS | RORER PHARMACEUTICAL CORPORATION (US) | 1990-05-08 | — | — | US | disclosed |
| US-4859683-A | Certain benzoxepins and their pharmaceutical compositions and methods | RORER PHARMACEUTICAL CORPORATION (US) | 1989-08-22 | — | — | US | disclosed |
| US-4857517-A | Quinuclidyl benzoxepins as 5-HT3 antagonists | RORER PHARMACEUTICAL CORPORATION (US) | 1989-08-15 | — | — | US | disclosed |
| CN-87100978-A | Dihydrobenzofuran-and chroman-carboxamide derivatives, processes for their preparation and their use as neuroleptics | — | 1987-09-16 | — | — | CN | disclosed |