Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CDK4 | P11802 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | CCND1 | P24385 | 1/20 | 0.46 |
| ▸ | MGLL | Q99685 | 1/20 | 0.45 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30486084 | 0.84 | SIGMAR1 (0.52) | ALDH1A1MEN1KMT2ANOTUMSMN1; SMN2 | |
| SCHEMBL29933410 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2ANOTUMSMN1; SMN2 | |
| SCHEMBL1437753 | 0.81 | ALDH1A1 (0.60) | ALDH1A1MEN1KMT2ANOTUMSMN1; SMN2 | |
| SCHEMBL5467606 | 0.78 | ALDH1A1 (0.46) | ALDH1A1MEN1KMT2ANOTUMSMN1; SMN2 | |
| SCHEMBL27181453 | 0.78 | SIGMAR1 (0.46) | ALDH1A1MEN1KMT2ANOTUMSMN1; SMN2 | |
| SCHEMBL23051598 | 0.77 | ALDH1A1 (0.45) | ALDH1A1MEN1KMT2ANOTUMSMN1; SMN2 | |
| SCHEMBL7954957 | 0.77 | SMN1; SMN2 (0.49) | ALDH1A1MEN1KMT2ANOTUMSMN1; SMN2 | |
| SCHEMBL10441142 | 0.77 | SMN1; SMN2 (0.49) | ALDH1A1MEN1KMT2ANOTUMSMN1; SMN2 | |
| SCHEMBL5410892 | 0.76 | ALDH1A1 (0.54) | ALDH1A1MEN1KMT2ANOTUMSMN1; SMN2 | |
| SCHEMBL11877694 | 0.75 | ALDH1A1 (0.44) | ALDH1A1MEN1KMT2ANOTUMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048295-A1 | SUBSTITUTED 5,6,7,8-TETRAHYDROQUINOLINE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE THEREOF | JANSSEN PHARMACEUTICE N.V. (BE) | 2009-02-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090048295-A1 | SUBSTITUTED 5,6,7,8-TETRAHYDROQUINOLINE DERIVATIVES, COMPOSITIONS, AND METHODS OF USE THEREOF | C3AR1, C5AR1, C5AR2 | ALDH1A1 3130/4885MEN1 2958/4885KMT2A 4326/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.