SCHEMBL4127528

SCHEMBL4127528

CCOCc1nc2c(N)nc3ccccc3c2n1CC(C)(C)NC(=O)CCC(=O)NNC(=O)OC(C)(C)C

nearest known ligand 0.63

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
TLR7 Q9NYK1 19/20 0.63
TLR8 Q9NR97 11/20 0.63
NUDT1 P36639 1/20 0.63

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4705732 0.92 TLR7 (0.67) TLR7TLR8NUDT1
SCHEMBL1042379 0.91 TLR7 (0.70) TLR7TLR8NUDT1
SCHEMBL4129145 0.90 TLR7 (0.69) TLR7TLR8NUDT1
SCHEMBL29371111 0.87 TLR7 (0.71) TLR7TLR8NUDT1
SCHEMBL3863883 0.87 TLR7 (0.71) TLR7TLR8NUDT1
SCHEMBL23255722 0.86 TLR7 (0.66) TLR7TLR8NUDT1
SCHEMBL4125001 0.85 TLR7 (0.67) TLR7TLR8NUDT1
SCHEMBL4135322 0.85 TLR7 (0.46) TLR7TLR8NUDT1
SCHEMBL18166871 0.85 TLR7 (0.62) TLR7TLR8NUDT1
Hydrochloric Acid SCHEMBL4134550 0.85 TLR7 (0.66) TLR7TLR8NUDT1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10472420-B2 Immune response modifier conjugates 3M INNOVATIVE PROPERTIES COMPANY (US) 2019-11-12 US disclosed
EP-3085373-A1 IMMUNE RESPONSE MODIFIER CONJUGATES 3M Innovative Properties Company (US) 2016-10-26 EP disclosed
US-20150141625-A1 IMMUNE RESPONSE MODIFIER CONJUGATES SOLVENTUM INTELLECTUAL PROPERTIES COMPANY 2015-05-21 US disclosed
US-8951528-B2 Immune response modifier conjugates 3M INNOVATIVE PROPERTIES COMPANY (US) 2015-02-10 US disclosed
US-20090035323-A1 IMMUNE RESPONSE MODIFIER CONJUGATES SOLVENTUM INTELLECTUAL PROPERTIES COMPANY 2009-02-05 US disclosed
US-20060142202-A1 Compositions and methods for targeted delivery of immune response modifiers 3M INNOVATIVE PROPERTIES COMPANY 2006-06-29 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150141625-A1 IMMUNE RESPONSE MODIFIER CONJUGATES IFNG, CD74, MYD88 TLR7 92/4885TLR8 71/4885NUDT1 3151/4885
US-20060142202-A1 Compositions and methods for targeted delivery of immune response modifiers CD47, IFNG, CLEC4M TLR7 84/4885TLR8 57/4885NUDT1 4367/4885
US-20090035323-A1 IMMUNE RESPONSE MODIFIER CONJUGATES IFNG, CD74, MYD88 TLR7 92/4885TLR8 71/4885NUDT1 3151/4885
US-10472420-B2 Immune response modifier conjugates IFNG, CD74, MYD88 TLR7 92/4885TLR8 71/4885NUDT1 3151/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.