Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGLL | Q99685 | 2/20 | 0.49 |
| ▸ | PTPN1 | P18031 | 7/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 4/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | PTGIR | P43119 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | BRAF | P15056 | 1/20 | 0.36 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4141672 | 0.88 | PTPN1 (0.49) | PTPN1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL4121429 | 0.86 | PTPN1 (0.55) | MGLLPTPN1PTGIR | |
| SCHEMBL4125985 | 0.86 | PTPN1 (0.41) | PTPN1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3191962 | 0.81 | ALDH1A1 (0.40) | MGLLPTPN1ALDH1A1LMNAMAPT | |
| SCHEMBL4127835 | 0.81 | ALDH1A1 (0.36) | PTPN1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL4131939 | 0.80 | HSD17B10 (0.41) | PTPN1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3181104 | 0.79 | NLRP3 (0.38) | MGLLCHRM3ALDH1A1PTGIRHDAC3 | |
| SCHEMBL4131867 | 0.79 | ALDH1A1 (0.34) | PTPN1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL4139259 | 0.78 | POLB (0.36) | PTPN1ALDH1A1LMNAMAPTSMN1; SMN2 | |
| SCHEMBL3906667 | 0.77 | PTPN1 (0.57) | MGLLPTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | MGLL 2574/4885PTPN1 11/4885CHRM3 4871/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | MGLL 2574/4885PTPN1 11/4885CHRM3 4871/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.