Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR3C1 | P04150 | 9/20 | 0.46 |
| ▸ | NR3C2 | P08235 | 6/20 | 0.46 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | PGR | P06401 | 3/20 | 0.34 |
| ▸ | RIPK1 | Q13546 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CTSS | P25774 | 1/20 | 0.33 |
| ▸ | CTSK | P43235 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4039578 | 0.81 | NR3C1 (0.71) | NR3C1NR3C2PGR | |
| SCHEMBL4128078 | 0.81 | NR3C1 (0.59) | NR3C1NR3C2PGR | |
| SCHEMBL4122397 | 0.77 | NR3C1 (0.51) | NR3C1NR3C2PGR | |
| SCHEMBL4138205 | 0.74 | NR3C1 (0.61) | NR3C1NR3C2PGR | |
| SCHEMBL5208282 | 0.73 | NR3C1 (0.55) | NR3C1NR3C2PGRMEN1KMT2A | |
| SCHEMBL27774909 | 0.73 | NR3C1 (0.54) | NR3C1NR3C2PGRMEN1KMT2A | |
| SCHEMBL3378915 | 0.72 | RIPK1 (0.48) | RIPK1MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL3819478 | 0.72 | RIPK1 (0.48) | RIPK1MAPK1MEN1KMT2AALDH1A1 | |
| SCHEMBL27176519 | 0.72 | KMT2A (0.40) | KMT2AALDH1A1CTSS | |
| SCHEMBL3536311 | 0.72 | KRAS (0.37) | TAAR1SLC6A2SLC6A4SLC6A3KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2049112-A2 | TREATING INFECTIONS AND SEQUELAE THEREOF WITH COMBINED DISSOCIATED GLUCOCORTICOID RECEPTOR AGONISTS AND ANTI-INFECTIVE AGENTS | Bausch & Lomb Incorporated (US) | 2009-04-22 | — | — | EP | disclosed |
| WO-2008021728-A2 | TREATING INFECTIONS AND SEQUELAE THEREOF WITH COMBINED DISSOCIATED' GLUCOCORTICOID RECEPTOR AGONISTS AND ANTI-INFECTIVE AGENTS | BAUSCH & LOMB INCORPORATED (US) | 2008-02-21 | — | — | WO | disclosed |