Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.36 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.36 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.36 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.35 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.35 |
| ▸ | KDM4A | O75164 | 2/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.35 |
| ▸ | TET3 | O43151 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.34 |
| ▸ | GABRP | O00591 | 2/20 | 0.34 |
| ▸ | GABRD | O14764 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL5368117 | 1.00 | TP53 (0.44) | TP53LMNASLC15A2CYP1A2EGLN1 | |
| Succinic Acid SCHEMBL7929359 | 0.94 | TP53 (0.39) | TP53LMNASLC15A2CYP1A2EGLN1 | |
| Succinic Acid SCHEMBL9714183 | 0.92 | TP53 (0.52) | TP53LMNASLC15A2CYP1A2EGLN1 | |
| Succinic Acid SCHEMBL27552607 | 0.90 | TP53 (0.50) | TP53LMNASLC15A2CYP1A2EGLN1 | |
| Succinic Acid SCHEMBL27741043 | 0.88 | TP53 (0.48) | TP53LMNASLC15A2CYP1A2EGLN1 | |
| Succinic Acid SCHEMBL5309775 | 0.87 | LMNA (0.50) | LMNASLC15A2EGLN1ALKBH5SUCNR1 | |
| Lactic Acid SCHEMBL14842182 | 0.87 | TP53 (0.58) | TP53CYP1A2HDAC1HDAC2FFAR1 | |
| Malic Acid SCHEMBL18396636 | 0.86 | SMN1; SMN2 (0.44) | TP53CYP1A2TET2KDM2AKDM4A | |
| Succinic Acid SCHEMBL8827899 | 0.85 | TP53 (0.61) | TP53LMNASLC15A2CYP1A2EGLN1 | |
| Succinic Acid SCHEMBL27677676 | 0.84 | FFAR3 (0.43) | TP53LMNASLC15A2CYP1A2FFAR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2041293-A2 | ETHANOL PRODUCTION IN NON-RECOMBINANT HOSTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2009-04-01 | — | — | EP | disclosed |
| WO-2008018930-A2 | ETHANOL PRODUCTION IN NON-RECOMBINANT HOSTS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2008-02-14 | — | — | WO | disclosed |
| WO-2005086670-A2 | PRODUCTION OF CHEMICALS FROM LIGNOCELLULOSE, BIOMASS OR SUGARS | UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. (US) | 2005-09-22 | — | — | WO | disclosed |