Known targets — ChEMBL curated mechanism
ADRB1CDK4CDK6CHRM2CHRM3DPP4DRD2DRD3DRD4EGFRHRH1HTR1BHTR1DHTR1FHTR2AHTR2CHTR4SLC6A2SLC6A4
The experimentally established mechanism targets of Succinic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | SLC15A2 | Q16348 | 1/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.43 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.43 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.43 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.42 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.42 |
| ▸ | TET2 | Q6N021 | 3/20 | 0.41 |
| ▸ | KDM2A | Q9Y2K7 | 3/20 | 0.41 |
| ▸ | KDM4A | O75164 | 2/20 | 0.41 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.41 |
| ▸ | TET3 | O43151 | 1/20 | 0.41 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinic Acid SCHEMBL27552607 | 0.98 | TP53 (0.50) | TP53LMNASLC15A2CYP1A2EGLN1 | |
| Succinic Acid SCHEMBL27741043 | 0.96 | TP53 (0.48) | TP53LMNASLC15A2CYP1A2EGLN1 | |
| Succinic Acid SCHEMBL8827899 | 0.93 | TP53 (0.61) | TP53LMNASLC15A2CYP1A2EGLN1 | |
| Succinic Acid SCHEMBL5368117 | 0.92 | TP53 (0.44) | TP53LMNASLC15A2CYP1A2EGLN1 | |
| Succinic Acid SCHEMBL4128426 | 0.92 | TP53 (0.44) | TP53LMNASLC15A2CYP1A2EGLN1 | |
| Lactic Acid SCHEMBL21464736 | 0.91 | FFAR3 (0.56) | TP53CYP1A2FFAR3HDAC3HDAC1 | |
| Lactic Acid SCHEMBL2332415 | 0.90 | TP53 (0.65) | TP53FFAR3HDAC1HDAC2FFAR1 | |
| Lactic Acid SCHEMBL725207 | 0.90 | TP53 (0.65) | TP53FFAR3HDAC1HDAC2FFAR1 | |
| Lactic Acid SCHEMBL8734273 | 0.88 | TP53 (0.55) | TP53CYP1A2FFAR3HDAC1HDAC2 | |
| Lactic Acid SCHEMBL12505872 | 0.87 | TP53 (0.61) | TP53FFAR3HDAC1HDAC2FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992016615-A1 | ETHANOL PRODUCTION BY RECOMBINANT HOSTS | UNIVERSITY OF FLORIDA (US) | 1992-10-01 | — | — | WO | disclosed |