Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | CAMK2A | Q9UQM7 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.43 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.41 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.40 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | HTR2C | P28335 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4132233 | 0.76 | NPSR1 (0.40) | NPSR1OPRL1CACNA1G | |
| SCHEMBL4127471 | 0.75 | SLC18A3 (0.45) | CYP1A2CYP2D6CYP2C9CYP2C19CAMK2A | |
| SCHEMBL4127463 | 0.75 | SLC18A3 (0.45) | CYP1A2CYP2D6CYP2C9CYP2C19CAMK2A | |
| SCHEMBL4127466 | 0.75 | SLC18A3 (0.45) | CYP1A2CYP2D6CYP2C9CYP2C19CAMK2A | |
| SCHEMBL10559202 | 0.73 | NPSR1 (0.41) | NPSR1CACNA1GL3MBTL1 | |
| SCHEMBL917328 | 0.73 | NPSR1 (0.46) | NPSR1CACNA1G | |
| SCHEMBL4128332 | 0.71 | SLC18A3 (0.41) | CYP1A2CYP2D6CYP2C9CYP2C19CAMK2A | |
| SCHEMBL4128329 | 0.71 | SLC18A3 (0.41) | CYP1A2CYP2D6CYP2C9CYP2C19CAMK2A | |
| SCHEMBL4128336 | 0.71 | SLC18A3 (0.41) | CYP1A2CYP2D6CYP2C9CYP2C19CAMK2A | |
| SCHEMBL17540703 | 0.70 | CHRNA7 (0.53) | CYP1A2CYP2C9CYP2C19NPSR1OPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7612061-B2 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-11-03 | — | — | US | disclosed |
| US-20090076030-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-03-19 | — | — | US | disclosed |
| US-20090075982-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2009-03-19 | — | — | US | disclosed |
| US-7465733-B2 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2008-12-16 | — | — | US | disclosed |
| EP-1710240-B1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | SERVIER LAB (FR) | 2007-12-05 | — | — | EP | disclosed |
| US-20060229318-A1 | Piperazine compounds | LES LABORATOIRES SERVIER (FR) | 2006-10-12 | — | — | US | disclosed |
| WO-2006106241-A1 | PIPERAZINE DERIVATIVES AND USE THEREOF AS SEROTONIN REUPTAKE INHIBITORS OR AS NEUROKININ ANTAGONISTS | LES LABORATOIRES SERVIER (FR) | 2006-10-12 | — | — | WO | disclosed |
| EP-1710240-A1 | Piperazine derivatives and their use as serotonin reuptake inhibitors or as neurokinin antagonists | Les Laboratoires Servier (FR) | 2006-10-11 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090075982-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | CYP1A2 172/4885CYP2D6 420/4885CYP2C9 674/4885 |
| US-20090076030-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | CYP1A2 172/4885CYP2D6 420/4885CYP2C9 674/4885 |
| US-20060229318-A1 | Piperazine compounds | HTR7, HTR5A, NPY5R | CYP1A2 172/4885CYP2D6 420/4885CYP2C9 674/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.