Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.39 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.38 |
| ▸ | DRD2 | P14416 | 2/20 | 0.38 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.38 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.38 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.38 |
| ▸ | DRD4 | P21917 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.37 |
| ▸ | AR | P10275 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553887 | 0.98 | MTNR1A (0.52) | MTNR1AALDH1A1MEN1KMT2ABRD4 | |
| SCHEMBL22977707 | 0.98 | MTNR1A (0.52) | MTNR1AALDH1A1MEN1KMT2ABRD4 | |
| SCHEMBL29593079 | 0.98 | MTNR1A (0.52) | MTNR1AALDH1A1MEN1KMT2ABRD4 | |
| SCHEMBL4045997 | 0.95 | MTNR1A (0.55) | MTNR1AALDH1A1MEN1KMT2ABRD4 | |
| SCHEMBL4138599 | 0.89 | MTNR1A (0.57) | MTNR1ABRD4CREBBPDRD2AR | |
| SCHEMBL7951734 | 0.85 | MTNR1A (0.55) | MTNR1ABRD4CREBBP | |
| SCHEMBL19987645 | 0.84 | ALDH1A1 (0.48) | MTNR1AALDH1A1MEN1KMT2ABRD4 | |
| SCHEMBL6243720 | 0.84 | MTNR1A (0.45) | MTNR1AALDH1A1DRD2CHRM2CHRM4 | |
| SCHEMBL13994797 | 0.84 | MTNR1A (0.50) | MTNR1AMEN1KMT2ADRD2CHRM2 | |
| SCHEMBL18668694 | 0.83 | MTNR1A (0.46) | MTNR1ACREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105017266-A | Chiral 2-aryl-1,2,3,4-tetrahydroquinoline compound and synthesis method thereof | UNIV ANHUI AGRICULTURAL | 2015-11-04 | — | — | CN | claimed |
| EP-2188259-B1 | QUINOLINE DERIVATIVES AS ANTI-CANCER AGENTS | UNIV HONG KONG POLYTECHNIC (CN) | 2013-11-06 | — | — | EP | claimed |
| US-20090054482-A1 | Method of making and administering quinoline derivatives as anti-cancer agents | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2009-02-26 | — | — | US | claimed |
| EP-0256503-B1 | PYRIDINECARBOXAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDE | MITSUBISHI KASEI CORPORATION (JP) | 1992-12-02 | — | — | EP | claimed |
| EP-0256503-A2 | Pyridinecarboxamide derivatives and their use as fungicide | MITSUBISHI KASEI CORPORATION (JP) | 1988-02-24 | — | — | EP | claimed |
| CN-112409253-B | Method for synthesizing chiral alpha-tertiary amine by catalytic kinetic resolution | 上海科技大学 | 2022-11-29 | — | — | CN | disclosed |
| CN-109071439-B | Process for preparing 4-aminoindane derivatives and related aminoindane amides | I-F产品协作基金会 | 2022-07-15 | — | — | CN | disclosed |
| CN-112409253-A | Method for synthesizing chiral alpha-tertiary amine by catalytic kinetic resolution | 上海科技大学 | 2021-02-26 | — | — | CN | disclosed |
| US-9321730-B2 | Method of making and administering quinoline derivatives as anti-cancer agents | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2016-04-26 | — | — | US | disclosed |
| US-9321730-B2 | Method of making and administering quinoline derivatives as anti-cancer agents | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2016-04-26 | — | — | US | disclosed |
| US-9321730-B2 | Method of making and administering quinoline derivatives as anti-cancer agents | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2016-04-26 | — | — | US | disclosed |
| CN-105017266-A | Chiral 2-aryl-1,2,3,4-tetrahydroquinoline compound and synthesis method thereof | UNIV ANHUI AGRICULTURAL | 2015-11-04 | — | — | CN | disclosed |
| US-20070275992-A1 | Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers | LI CHAO-JUN | 2007-11-29 | — | — | US | disclosed |
| US-7250423-B2 | Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers | LI, CHAO-JUN | 2007-07-31 | — | — | US | disclosed |
| US-20030149069-A1 | Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers | LI, CHAO-JUN | 2003-08-07 | — | — | US | disclosed |
| EP-0937045-A1 | N-ARYL SUBSTITUTED TETRAHYDROQUINOLINES LIGANDS FOR RETINOID RECEPTORS HAVING AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE ACTIVITY | Allergan Sales, Inc. (US) | 1999-08-25 | — | — | EP | disclosed |
| WO-1998019999-A1 | N-ARYL SUBSTITUTED TETRAHYDROQUINOLINES LIGANDS FOR RETINOID RECEPTORS HAVING AGONIST, ANTAGONIST OR INVERSE AGONIST TYPE ACTIVITY | ALLERGAN SALES, INC. (US) | 1998-05-14 | — | — | WO | disclosed |
| EP-0256503-B1 | PYRIDINECARBOXAMIDE DERIVATIVES AND THEIR USE AS FUNGICIDE | MITSUBISHI KASEI CORPORATION (JP) | 1992-12-02 | — | — | EP | disclosed |
| US-4840959-A | Pyridinecarboxamide derivatives and their use as fungicide | MITSUBISHI CHEMICAL INDUSTRIES LIMITED (JP) | 1989-06-20 | — | — | US | disclosed |
| EP-0256503-A2 | Pyridinecarboxamide derivatives and their use as fungicide | MITSUBISHI KASEI CORPORATION (JP) | 1988-02-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070275992-A1 | Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers | HCCS, DPYD, TYMS | MTNR1A 4176/4885ALDH1A1 1166/4885MEN1 578/4885 |
| US-20030149069-A1 | Methods for synthesizing heterocycles and therapeutic use of the heterocycles for cancers | HCCS, DPYD, TYMS | MTNR1A 4176/4885ALDH1A1 1166/4885MEN1 578/4885 |
| US-20090054482-A1 | Method of making and administering quinoline derivatives as anti-cancer agents | HCCS, GLS2, NQO1 | MTNR1A 1442/4885ALDH1A1 959/4885MEN1 1575/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.