SCHEMBL413095

SCHEMBL413095

COC(=O)c1ccc(NCc2cc(O)ccc2O)cc1O

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
EGFR P00533 17/20 1.00
HKDC1 Q2TB90 1/20 0.71
NOX4 Q9NPH5 2/20 0.63
RGS12 O14924 1/20 0.63
ALDH1A1 P00352 1/20 0.63
LCK P06239 1/20 0.63
MAPT P10636 1/20 0.63
CAMKK2 Q96RR4 1/20 0.63
TDP1 Q9NUW8 1/20 0.63
CA12 O43570 1/20 0.60
CA1 P00915 1/20 0.60
CA2 P00918 1/20 0.60
CA7 P43166 1/20 0.60
PDK2 Q15119 1/20 0.60
PDK4 Q16654 1/20 0.60
CA9 Q16790 1/20 0.60
CA14 Q9ULX7 1/20 0.60

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29607886 0.90 EGFR (1.00) EGFRHKDC1NOX4RGS12ALDH1A1
SCHEMBL7809216 0.85 EGFR (0.81) EGFRHKDC1NOX4RGS12ALDH1A1
SCHEMBL5794016 0.83 HKDC1 (1.00) EGFRHKDC1ALDH1A1CA1CA2
SCHEMBL8628971 0.79 EGFR (1.00) EGFRNOX4RGS12ALDH1A1LCK
SCHEMBL1705430 0.78 EGFR (0.75) EGFRHKDC1NOX4RGS12ALDH1A1
SCHEMBL6259074 0.78 EGFR (0.66) EGFRHKDC1NOX4CA12CA1
SCHEMBL15763208 0.78 SMN1; SMN2 (0.64) EGFRHKDC1NOX4TDP1CA12
Lavendustin C SCHEMBL30569227 0.77 EGFR (1.00) EGFRNOX4RGS12ALDH1A1LCK
Lavendustin C SCHEMBL1821516 0.77 EGFR (1.00) EGFRNOX4RGS12ALDH1A1LCK
Methyl 2,4-Dihydroxybenzoate SCHEMBL30917273 0.77 CA12 (1.00) EGFRALDH1A1MAPTCA12CA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120021519-A1 EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS PRESIDENTS AND FELLOWS OF HARVARD COLLEGE (US) 2012-01-26 US disclosed
WO-2010033906-A2 EFFICIENT INDUCTION OF PLURIPOTENT STEM CELLS USING SMALL MOLECULE COMPOUNDS PRESIDENT AND FELLOWS OF HARVARD COLLEGE (US) 2010-03-25 WO disclosed