Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 19/20 | 1.00 |
| ▸ | RGS12 | O14924 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.67 |
| ▸ | LCK | P06239 | 1/20 | 0.67 |
| ▸ | MAPT | P10636 | 1/20 | 0.67 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.67 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.67 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.67 |
| ▸ | CA12 | O43570 | 1/20 | 0.65 |
| ▸ | CA1 | P00915 | 1/20 | 0.65 |
| ▸ | CA2 | P00918 | 1/20 | 0.65 |
| ▸ | CA7 | P43166 | 1/20 | 0.65 |
| ▸ | CA9 | Q16790 | 1/20 | 0.65 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29607886 | 0.88 | EGFR (1.00) | EGFRRGS12ALDH1A1LCKMAPT | |
| Lavendustin C SCHEMBL30569227 | 0.81 | EGFR (1.00) | EGFRRGS12ALDH1A1LCKMAPT | |
| Lavendustin C SCHEMBL1821516 | 0.81 | EGFR (1.00) | EGFRRGS12ALDH1A1LCKMAPT | |
| SCHEMBL29457603 | 0.80 | CA12 (1.00) | EGFRCA12CA1CA2CA7 | |
| SCHEMBL39259 | 0.80 | CA12 (1.00) | EGFRCA12CA1CA2CA7 | |
| SCHEMBL17240955 | 0.79 | EGFR (1.00) | EGFRRGS12ALDH1A1LCKMAPT | |
| SCHEMBL413095 | 0.79 | EGFR (1.00) | EGFRRGS12ALDH1A1LCKMAPT | |
| SCHEMBL14400343 | 0.77 | EGFR (0.62) | EGFRALDH1A1NOX4CA12CA1 | |
| SCHEMBL1705430 | 0.76 | EGFR (0.75) | EGFRRGS12ALDH1A1LCKMAPT | |
| SCHEMBL10172851 | 0.76 | EGFR (0.72) | EGFRRGS12ALDH1A1LCKMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850055-A2 | PROTEIN TYROSINE KINASE INHIBITORS FOR TREATING OSTEOARTHRITIS | Osteoarthritis Sciences, Inc. (US) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997011692-A2 | PROTEIN TYROSINE KINASE INHIBITORS FOR TREATING OSTEOARTHRITIS | OSTEOARTHRITIS SCIENCES, INC. (US) | 1997-04-03 | — | — | WO | disclosed |