Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 6/20 | 0.49 |
| ▸ | CHRM3 known ✓ | P20309 | 6/20 | 0.49 |
| ▸ | CHRM2 known ✓ | P08172 | 5/20 | 0.46 |
| ▸ | ACHE known ✓ | P22303 | 2/20 | 0.36 |
| ▸ | CHRM5 | P08912 | 6/20 | 0.49 |
| ▸ | CHRM4 | P08173 | 5/20 | 0.46 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | HTR1A | P08908 | 2/20 | 0.46 |
| ▸ | PGR | P06401 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.46 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.46 |
| ▸ | CHRNA10 | Q9GZZ6 | 1/20 | 0.46 |
| ▸ | CHRNA9 | Q9UGM1 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | BLM | P54132 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL3945710 | 0.94 | CHRM5 (0.44) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Methacrylic Acid SCHEMBL21931217 | 0.89 | CHRM5 (0.57) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Methacrylic Acid SCHEMBL2511701 | 0.89 | CHRM5 (0.57) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acrylic Acid Ethyl Ester SCHEMBL13519363 | 0.88 | THRB (0.39) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Methacrylic Acid SCHEMBL16444097 | 0.87 | CHRM5 (0.55) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Acetic Acid SCHEMBL9619910 | 0.87 | CHRM5 (0.59) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL8612391 | 0.85 | THRB (0.42) | CHRM5CHRM1CHRM3CHRM2APEX1 | |
| Hydrochloric Acid SCHEMBL15954 | 0.85 | CHRM5 (0.65) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| SCHEMBL180003 | 0.85 | CHRM5 (0.65) | CHRM5CHRM1CHRM3CHRM2CHRM4 | |
| Hydrochloric Acid SCHEMBL30183040 | 0.85 | CHRM5 (0.65) | CHRM5CHRM1CHRM3CHRM2CHRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2079450-A2 | METHOD OF PREPARING SOLID DOSAGE FORMS OF MULTI-PHASIC PHARMACEUTICAL COMPOSITIONS | Novavax, INC. (US) | 2009-07-22 | — | — | EP | claimed |
| WO-2008063910-A2 | METHOD OF PREPARING SOLID DOSAGE FORMS OF MULTI-PHASIC PHARMACEUTICAL COMPOSITIONS | NOVAVAX, INC. (US) | 2008-05-29 | — | — | WO | claimed |
| EP-2079450-A2 | METHOD OF PREPARING SOLID DOSAGE FORMS OF MULTI-PHASIC PHARMACEUTICAL COMPOSITIONS | Novavax, INC. (US) | 2009-07-22 | — | — | EP | disclosed |
| EP-2059518-A2 | SALTS OF BENZIMIDAZOLYL PYRIDYL ETHERS AND FORMULATIONS THEREOF | Novartis AG (CH) | 2009-05-20 | — | — | EP | disclosed |
| EP-2051702-A1 | MULTI-PHASIC PHARMACEUTICAL FORMULATIONS OF POORLY WATER-SOLUBLE DRUGS FOR REDUCED FED/FASTED VARIABILITY AND IMPROVED ORAL BIOAVAILABILITY | Novavax, Inc. (US) | 2009-04-29 | — | — | EP | disclosed |
| EP-2046292-A2 | FORMULATIONS FOR BENZIMIDAZOLYL PYRIDYL ETHERS | Novartis AG (CH) | 2009-04-15 | — | — | EP | disclosed |
| WO-2008091855-A1 | MULTI-PHASIC PHARMACEUTICAL FORMULATIONS OF POORLY WATER-SOLUBLE DRUGS FOR REDUCED FED/FASTED VARIABILITY AND IMPROVED ORAL BIOAVAILABILITY | NOVAVAX, INC. (US) | 2008-07-31 | — | — | WO | disclosed |
| WO-2008063910-A2 | METHOD OF PREPARING SOLID DOSAGE FORMS OF MULTI-PHASIC PHARMACEUTICAL COMPOSITIONS | NOVAVAX, INC. (US) | 2008-05-29 | — | — | WO | disclosed |
| WO-2008027523-A2 | SALTS OF BENZIMIDAZOLYL PYRIDYL ETHERS AND FORMULATIONS THEREOF | NOVARTIS AG (CH) | 2008-03-06 | — | — | WO | disclosed |
| WO-2008011154-A2 | FORMULATIONS FOR BENZIMIDAZOLYL PYRIDYL ETHERS | NOVARTIS AG (CH) | 2008-01-24 | — | — | WO | disclosed |