Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | SMO | Q99835 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 5/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.38 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | PKM | P14618 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | FPR2 | P25090 | 1/20 | 0.38 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.38 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3752645 | 0.84 | ALDH1A1 (0.54) | KMT2AEPHX1ALDH1A1KDM4EPKM | |
| SCHEMBL10388448 | 0.80 | ALDH1A1 (0.43) | MEN1KMT2AEPHX1ALDH1A1MAPT | |
| SCHEMBL27093069 | 0.76 | TP53 (0.52) | MEN1KMT2AEPHX1ALDH1A1MAPT | |
| SCHEMBL1096056 | 0.75 | ESR1 (0.49) | KMT2AEPHX1ALDH1A1UTS2R | |
| SCHEMBL5337633 | 0.74 | NR4A2 (0.47) | PKMSMN1; SMN2 | |
| SCHEMBL5337173 | 0.74 | PPARG (0.40) | PPARAPPARGMEN1KMT2AALDH1A1 | |
| SCHEMBL27726511 | 0.73 | EPHX1 (0.52) | EPHX1ALDH1A1HTTPKMNCOA1 | |
| SCHEMBL11845837 | 0.73 | EPHX1 (0.52) | EPHX1ALDH1A1HTTPKMNCOA1 | |
| SCHEMBL9067637 | 0.73 | EPHX1 (0.52) | EPHX1ALDH1A1HTTPKMNCOA1 | |
| SCHEMBL15666527 | 0.73 | MBTD1 (0.45) | PPARAPPARGEPHX1ALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | WYETH (US) | 2009-02-19 | — | — | US | disclosed |
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | WYETH | 2005-09-15 | — | — | US | disclosed |
| WO-2005081960-A2 | INHIBITORS OF PROTEIN TYROSINE PHOSPHATASE 1B | WYETH (US) | 2005-09-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050203081-A1 | Inhibitors of protein tyrosine phosphatase 1B | PTPRS, PTPRO, PTPRM | PPARA 1638/4885PPARG 1685/4885SMO 3162/4885 |
| US-20090048286-A1 | Inhibitors of Protein Tyrosine Phosphatase 1B | PTPRS, PTPRO, PTPRM | PPARA 1638/4885PPARG 1685/4885SMO 3162/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.