Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
| ▸ | PDE2A | O00408 | 4/20 | 0.30 |
| ▸ | PDE6D | O43924 | 1/20 | 0.30 |
| ▸ | PDE5A | O76074 | 1/20 | 0.30 |
| ▸ | PDE6A | P16499 | 1/20 | 0.30 |
| ▸ | PDE6G | P18545 | 1/20 | 0.30 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE6B | P35913 | 1/20 | 0.30 |
| ▸ | PDE6C | P51160 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4893657 | 0.85 | KDM4E (0.43) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4131950 | 0.82 | GAA (0.41) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4117755 | 0.78 | KDM4E (0.41) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4904083 | 0.71 | KDM4E (0.48) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4898303 | 0.70 | PDE5A (0.48) | KDM4EALDH1A1POLBKMT2APDE5A | |
| SCHEMBL3996853 | 0.69 | GAA (0.42) | KDM4EALDH1A1SMN1; SMN2POLBLMNA | |
| SCHEMBL14021008 | 0.68 | KDM4E (0.40) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4125332 | 0.68 | PDE5A (0.46) | KDM4EALDH1A1SMN1; SMN2LMNAKMT2A | |
| SCHEMBL14021139 | 0.67 | KDM4E (0.38) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 | |
| SCHEMBL4901385 | 0.67 | KDM4E (0.44) | KDM4EALDH1A1NPSR1MAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |