Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 2/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.34 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | GRIA2 | P42262 | 2/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 3/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8045132 | 0.86 | KDM4E (0.41) | KDM4ENPSR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4893657 | 0.83 | KDM4E (0.43) | KDM4ENPSR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL3995952 | 0.82 | KDM4E (0.39) | KDM4ENPSR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4128842 | 0.80 | KDM4E (0.35) | KDM4ENPSR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8042659 | 0.80 | KDM4E (0.37) | KDM4ENPSR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8049123 | 0.80 | KDM4E (0.37) | KDM4ENPSR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8046391 | 0.80 | KDM4E (0.35) | KDM4ENPSR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL8032546 | 0.80 | HCRTR1 (0.37) | KDM4ENPSR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4131950 | 0.78 | GAA (0.41) | KDM4ENPSR1ALDH1A1SMN1; SMN2MAPT | |
| SCHEMBL4132580 | 0.78 | KDM4E (0.35) | KDM4ENPSR1ALDH1A1SMN1; SMN2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |