Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | HPGD | P15428 | 3/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.36 |
| ▸ | PDE1A | P54750 | 1/20 | 0.36 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.36 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4143162 | 0.95 | GAA (0.42) | GAAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL3996853 | 0.88 | GAA (0.42) | GAAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL4125332 | 0.86 | PDE5A (0.46) | GAAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL4117316 | 0.82 | MAPK13 (0.43) | GAAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL4132815 | 0.82 | KDM4E (0.41) | ALDH1A1KDM4ESMN1; SMN2LMNATP53 | |
| SCHEMBL4123024 | 0.80 | ALDH1A1 (0.36) | GAAALDH1A1KDM4ESMN1; SMN2HPGD | |
| SCHEMBL4893657 | 0.80 | KDM4E (0.43) | GAAALDH1A1KDM4ESMN1; SMN2MAPK1 | |
| SCHEMBL4117755 | 0.78 | KDM4E (0.41) | ALDH1A1KDM4ESMN1; SMN2HSD17B10TSHR | |
| SCHEMBL8048797 | 0.77 | PDE9A (0.38) | GAAALDH1A1KDM4ESMN1; SMN2LMNA | |
| SCHEMBL4142307 | 0.77 | PDE5A (0.47) | GAAALDH1A1KDM4EHPGDHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |