Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CAPN1 | P07384 | 3/20 | 0.46 |
| ▸ | BMP1 | P13497 | 1/20 | 0.42 |
| ▸ | XIAP | P98170 | 2/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.39 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | CTSL | P07711 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
| ▸ | CTSS | P25774 | 2/20 | 0.37 |
| ▸ | CTSK | P43235 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13872553 | 0.94 | CAPN1 (0.48) | CAPN1BMP1XIAPCCR1HTR7 | |
| SCHEMBL4142864 | 0.86 | CAPN1 (0.51) | CAPN1BMP1CCR1TRPV4CTSL | |
| SCHEMBL4133200 | 0.82 | CAPN1 (0.48) | CAPN1BMP1CCR1TRPV4CTSL | |
| SCHEMBL4128798 | 0.82 | CAPN1 (0.47) | CAPN1BMP1CCR1TRPV4CTSL | |
| SCHEMBL4136304 | 0.80 | CAPN1 (0.53) | CAPN1BMP1CCR1TRPV4CTSL | |
| SCHEMBL5434636 | 0.79 | CAPN1 (0.51) | CAPN1BMP1CCR1TRPV4CTSL | |
| SCHEMBL4130678 | 0.78 | BMP1 (0.44) | CAPN1BMP1CCR1HTR7TRPV4 | |
| SCHEMBL4141710 | 0.76 | CAPN1 (0.49) | CAPN1BMP1CCR1TRPV4CTSL | |
| SCHEMBL4142303 | 0.76 | CAPN1 (0.48) | CAPN1BMP1CCR1TRPV4CTSL | |
| SCHEMBL4140140 | 0.76 | CAPN1 (0.43) | CAPN1BMP1CCR1TRPV4CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | claimed |
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | SMITHKLINE BEECHAM CORPORATION | 2009-04-23 | — | — | US | disclosed |
| WO-2007030761-A2 | ACYCLIC 1,4-DIAMINES AND USES THEREOF | SMITHKLINE BEECHAM CORPORATION (US) | 2007-03-15 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090105259-A1 | Acyclic 1,4-Diamines and Uses Thereof | TRPV4, TRPC4, TRPV1 | CAPN1 2031/4885BMP1 2172/4885XIAP 3588/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.