Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Tetrahydrofuran. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tetrahydrofuran SCHEMBL10660627 | 0.97 | TDP1 (0.53) | TDP1ALDH1A1TSHRUSP2PKM | |
| Dioxane SCHEMBL28127315 | 0.88 | TDP1 (0.62) | TDP1ALDH1A1TSHRUSP2PKM | |
| Tetrahydrofuran SCHEMBL10609672 | 0.86 | TSHR (0.53) | TDP1ALDH1A1TSHRPKMSMN1; SMN2 | |
| Propylene Glycol SCHEMBL9421374 | 0.85 | TDP1 (0.67) | TDP1ALDH1A1TSHRUSP2 | |
| Propylene Glycol SCHEMBL10407640 | 0.85 | — | — | |
| Propylene Glycol SCHEMBL78770 | 0.85 | — | — | |
| Tetrahydrofuran SCHEMBL10386650 | 0.83 | ALDH1A1 (0.44) | TDP1ALDH1A1TSHRUSP2PKM | |
| Tetrahydrofuran SCHEMBL28738577 | 0.83 | TSHR (0.50) | TDP1ALDH1A1TSHRPKMSMN1; SMN2 | |
| Tetrahydrofuran SCHEMBL23711833 | 0.83 | TSHR (0.56) | TDP1ALDH1A1TSHRUSP2PKM | |
| Tetrahydrofuran SCHEMBL154168 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109232851-B | Aliphatic waterborne polyurethane dispersion and waterborne dry adhesive for synthetic leather comprising same | 万华化学（宁波）有限公司 | 2021-04-20 | — | — | CN | claimed |
| US-4454301-A | POLYMER FROM ALKYL ACRYLAMIDOGLYCOLATE ALKYL ETHERS OR ACRYLAMIDOGLYCOAMIDE ALKYL ESTERS | AMERICAN CYANAMID COMPANY (US) | 1984-06-12 | — | — | US | claimed |
| CN-112209842-B | Polyamine synthesis method and polyamine | 深圳飞扬骏研新材料股份有限公司 | 2024-01-16 | — | — | CN | disclosed |
| CN-115505092-A | High-solid-content aqueous polyurethane resin and preparation method thereof | 青海师范大学 | 2022-12-23 | — | — | CN | disclosed |
| CN-109232851-B | Aliphatic waterborne polyurethane dispersion and waterborne dry adhesive for synthetic leather comprising same | 万华化学（宁波）有限公司 | 2021-04-20 | — | — | CN | disclosed |
| CN-110531582-A | Hardening resin composition and application thereof | NIPPON CATALYTIC CHEM IND | 2019-12-03 | — | — | CN | disclosed |
| CN-103576457-B | Curable resin composition and use thereof | 株式会社日本触媒 | 2019-10-25 | — | — | CN | disclosed |
| CN-106336739-A | Pigment dispersion for color filter, coloring composition for color filter, color filter and display device | DNP精细化工股份有限公司 | 2017-01-18 | — | — | CN | disclosed |
| US-20090010603-A1 | Resin Composition for Optical Packaging Material and Process for Preparing the Same, and Optical Packaging Material, Optical Packaging Component, and Optical Module | NIPPON SHOKUBAI CO., LTD. (JP) | 2009-01-08 | — | — | US | disclosed |
| EP-1079918-A1 | MICROENCAPSULATION AND ELECTROSTATIC PROCESSING METHOD | NASA/Johnson Space Center (US) | 2001-03-07 | — | — | EP | disclosed |
| WO-1999059714-A1 | MICROENCAPSULATION AND ELECTROSTATIC PROCESSING METHOD | NASA/JOHNSON SPACE CENTER (US) | 1999-11-25 | — | — | WO | disclosed |
| EP-0096230-B1 | CROSSLINKING COATING COMPOSITIONS | AMERICAN CYANAMID COMPANY (US) | 1986-12-03 | — | — | EP | disclosed |
| US-4454301-A | POLYMER FROM ALKYL ACRYLAMIDOGLYCOLATE ALKYL ETHERS OR ACRYLAMIDOGLYCOAMIDE ALKYL ESTERS | AMERICAN CYANAMID COMPANY (US) | 1984-06-12 | — | — | US | disclosed |
| EP-0096230-A1 | Crosslinking coating compositions | AMERICAN CYANAMID COMPANY (US) | 1983-12-21 | — | — | EP | disclosed |