Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.68 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.68 |
| ▸ | PIK3CB | P42338 | 5/20 | 0.68 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.60 |
| ▸ | MTOR | P42345 | 4/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.47 |
| ▸ | PIK3C2A | O00443 | 1/20 | 0.47 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.47 |
| ▸ | CHUK | O15111 | 1/20 | 0.47 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.47 |
| ▸ | PIK3C2G | O75747 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 1/20 | 0.47 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | TYK2 | P29597 | 1/20 | 0.47 |
| ▸ | FLT3 | P36888 | 1/20 | 0.47 |
| ▸ | CLK1 | P49759 | 1/20 | 0.47 |
| ▸ | CLK2 | P49760 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4145728 | 0.85 | PIK3CA (0.69) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL4128785 | 0.82 | PIK3CA (0.68) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL3554145 | 0.79 | KMT2A (0.44) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL4134049 | 0.78 | PIK3CA (0.69) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL14614250 | 0.77 | PIK3CA (0.69) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL5172881 | 0.76 | PIK3CA (1.00) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL4139135 | 0.75 | PIK3CA (0.74) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL4133831 | 0.74 | PIK3CA (0.72) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL15299524 | 0.74 | PIK3CA (1.00) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR | |
| SCHEMBL4138270 | 0.74 | ALDH1A1 (0.69) | PIK3CAPIK3CGPIK3CBPIK3CDMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090156601-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | F. HOFFMANN-LA ROCHE AG (CH) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156601-A1 | PYRIMIDINE DERIVATIVES FOR THE TREATMENT OF CANCER | NR3C1, NR4A3, NR4A1 | PIK3CA 137/4885PIK3CG 618/4885PIK3CB 377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.