Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RORB | Q92753 | 6/20 | 0.51 |
| ▸ | RORC | P51449 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.49 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.46 |
| ▸ | PTPRC | P08575 | 2/20 | 0.46 |
| ▸ | PTPRG | P23470 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.41 |
| ▸ | ALPL | P05186 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7472100 | 0.84 | BCAT2 (0.62) | RORBRORCKMT2ABCAT2GAA | |
| SCHEMBL953378 | 0.79 | KMT2A (0.52) | RORBMEN1KMT2APTPRCPTPRG | |
| SCHEMBL31540411 | 0.79 | BCAT2 (0.46) | RORBRORCMEN1KMT2ABCAT2 | |
| SCHEMBL31540417 | 0.79 | BCAT2 (0.46) | RORBRORCKMT2ABCAT2PTPRC | |
| SCHEMBL16472186 | 0.79 | HPGD (0.51) | MEN1KMT2ABCAT2PTPRCNPSR1 | |
| SCHEMBL1670982 | 0.77 | BCAT2 (0.72) | RORBMEN1KMT2ABCAT2PTPRC | |
| SCHEMBL14397435 | 0.76 | NPSR1 (0.49) | RORBRORCBCAT2PTPRCNPSR1 | |
| SCHEMBL28910605 | 0.76 | RORC (0.63) | RORBRORCMEN1KMT2ABCAT2 | |
| Bicarbonate SCHEMBL4865957 | 0.76 | CYP2A6 (0.59) | MEN1KMT2APTPRCNPSR1ALDH1A1 | |
| Bicarbonate SCHEMBL11009844 | 0.76 | CYP2A6 (0.59) | MEN1KMT2APTPRCNPSR1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2066675-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXYTHIENO[2,3-B]PYRIDINE-5-CARBONITRILES | Wyeth (US) | 2009-06-10 | — | — | EP | disclosed |
| WO-2008039414-A1 | PROCESS FOR THE PREPARATION OF 4-HYDROXYTHIENO[2,3-B]PYRIDINE-5-CARBONITRILES | WYETH (US) | 2008-04-03 | — | — | WO | disclosed |