Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 7/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.37 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.34 |
| ▸ | TNF | P01375 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.34 |
| ▸ | RELA | Q04206 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3956211 | 0.93 | HSP90AB1 (0.47) | HSP90AB1HSP90AA1KCNH2PIM1ALDH1A1 | |
| SCHEMBL3961239 | 0.91 | HSP90AA1 (0.56) | HSP90AB1HSP90AA1KCNH2SMN1; SMN2 | |
| SCHEMBL2567338 | 0.91 | HSP90AB1 (0.47) | HSP90AB1HSP90AA1KCNH2PIM1ALDH1A1 | |
| SCHEMBL3961248 | 0.90 | HSP90AB1 (0.56) | HSP90AB1HSP90AA1KCNH2LMNA | |
| SCHEMBL3955015 | 0.86 | HSP90AB1 (0.53) | HSP90AB1HSP90AA1KCNH2ALDH1A1KDM4E | |
| SCHEMBL3955735 | 0.86 | HSP90AA1 (0.62) | HSP90AB1HSP90AA1KCNH2SMN1; SMN2 | |
| SCHEMBL2569133 | 0.85 | HSP90AB1 (0.46) | HSP90AB1HSP90AA1KCNH2 | |
| SCHEMBL4064357 | 0.84 | HSP90AB1 (0.48) | HSP90AB1HSP90AA1KCNH2L3MBTL1 | |
| SCHEMBL2567033 | 0.84 | HSP90AB1 (0.44) | HSP90AB1HSP90AA1KCNH2PIM1ALDH1A1 | |
| SCHEMBL2564620 | 0.84 | HSP90AB1 (0.55) | HSP90AB1HSP90AA1KCNH2PIM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163490-A1 | Pyrrolopyrimidine Derivatives Used As HSP90 Inhibitors | VERNALIS (R&D) LTD. (GB) | 2009-06-25 | — | — | US | disclosed |
| US-20090163490-A1 | Pyrrolopyrimidine Derivatives Used As HSP90 Inhibitors | VERNALIS (R&D) LTD. (GB) | 2009-06-25 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163490-A1 | Pyrrolopyrimidine Derivatives Used As HSP90 Inhibitors | HSP90AA1, HSP90AB1, RAF1 | HSP90AB1 2/4885HSP90AA1 1/4885KCNH2 2202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.