Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Dipivefrin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 5/20 | 1.00 |
| ▸ | ADRB1 known ✓ | P08588 | 3/20 | 0.47 |
| ▸ | ADRA2A known ✓ | P08913 | 3/20 | 0.47 |
| ▸ | ADRB3 known ✓ | P13945 | 3/20 | 0.47 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.47 |
| ▸ | ADRA2C known ✓ | P18825 | 3/20 | 0.47 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.47 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.47 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.97 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.97 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.97 |
| ▸ | LMNA | P02545 | 2/20 | 0.97 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.49 |
| ▸ | BLM | P54132 | 4/20 | 0.49 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipivefrin SCHEMBL5275338 | 1.00 | ADRB2 (1.00) | ADRB2HIF1AALDH1A1CYP3A4LMNA | |
| Dipivefrin SCHEMBL41351 | 1.00 | ADRB2 (1.00) | ADRB2HIF1AALDH1A1CYP3A4LMNA | |
| Dipivefrin SCHEMBL18687014 | 1.00 | ADRB2 (1.00) | ADRB2HIF1AALDH1A1CYP3A4LMNA | |
| Dipivefrin SCHEMBL8071336 | 1.00 | ADRB2 (1.00) | ADRB2HIF1AALDH1A1CYP3A4LMNA | |
| Dipivefrin SCHEMBL29710905 | 0.99 | HIF1A (1.00) | ADRB2HIF1AALDH1A1CYP3A4LMNA | |
| Dipivefrin SCHEMBL20673238 | 0.99 | HIF1A (1.00) | ADRB2HIF1AALDH1A1CYP3A4LMNA | |
| Dipivefrin SCHEMBL24714 | 0.99 | HIF1A (1.00) | ADRB2HIF1AALDH1A1CYP3A4LMNA | |
| Dipivefrin SCHEMBL24713 | 0.99 | HIF1A (1.00) | ADRB2HIF1AALDH1A1CYP3A4LMNA | |
| Dipivefrin SCHEMBL3053588 | 0.96 | HIF1A (0.95) | ADRB2HIF1AALDH1A1CYP3A4LMNA | |
| Dipivefrin SCHEMBL8468680 | 0.91 | HIF1A (0.86) | ADRB2HIF1AALDH1A1CYP3A4LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 7963 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260076872-A1 | POLYMER VIALS WITH SUBSTANTIALLY FLAT BOTTOMS AND INJECTION STRETCH BLOW MOLDING METHODS FOR MAKING THE SAME | SIO2 MEDICAL PRODUCTS LLC (US) | 2026-03-19 | — | — | US | claimed |
| US-20250387363-A1 | LIQUID EPINEPHRINE PRODRUG FORMULATIONS AND LIQUID EPINEPHRINE FORMULATIONS | INSIGNIS THERAPEUTICS INC (US) | 2025-12-25 | — | — | US | claimed |
| US-20250242092-A1 | SiOx BARRIER FOR PHARMACEUTICAL PACKAGE AND COATING PROCESS | SIO2 MEDICAL PRODUCTS INC (US) | 2025-07-31 | — | — | US | claimed |
| US-12257371-B2 | SiOx barrier for pharmaceutical package and coating process | SIO2 MEDICAL PRODUCTS, LLC (US) | 2025-03-25 | — | — | US | claimed |
| CN-119677539-A | Combination therapy for modulating lipid production | 俄亥俄州创新基金会 | 2025-03-21 | — | — | CN | claimed |
| US-20250000821-A1 | METHODS OF USING DIPIVEFRIN | Insignis Therapeutics, Inc. | 2025-01-02 | — | — | US | claimed |
| EP-4098358-B1 | CATALYST AND CATALYTIC OXIDATION-DEOXIDATION METHOD FOR UNSATURATED HYDROCARBON-CONTAINING GAS | CHINA PETROLEUM & CHEM CORP (CN) | 2024-10-09 | — | — | EP | claimed |
| CN-117797151-A | Quinoline derivatives combined with chemotherapeutics for treating non-small cell lung cancer | 正大天晴药业集团股份有限公司 | 2024-04-02 | — | — | CN | claimed |
| US-20240074944-A1 | PECVD COATED PHARMACEUTICAL PACKAGING | OAKTREE FUND ADMINISTRATION, LLC | 2024-03-07 | — | — | US | claimed |
| US-20230303305-A1 | METHOD AND PACKAGE FOR REDUCING THE DEGRADATION OF A DRUG AND/OR EXCIPIENT, E.G. POLYSORBATE STABILIZER, IN A PHARMACEUTICAL PRODUCT | OAKTREE FUND ADMINISTRATION, LLC | 2023-09-28 | — | — | US | claimed |
| CN-1010307-B | Process for preparing N- [2- (4-fluorophenyl) -1-methyl ] -ethyl-N-methyl-N-propargylamine and isomers or salts thereof | CHINOIN GYOGYSZER ES VEGYESZET (HU) | 1990-11-07 | — | — | CN | claimed |
| CN-1046519-A | The method for preparing alkyl methacrylate | SHELL INT RESEARCH (NL) | 1990-10-31 | — | — | CN | claimed |
| CN-1045234-A | Carbonylating catalyst | SHELL INT RESEARCH (NL) | 1990-09-12 | — | — | CN | claimed |
| CN-1032670-A | Fuel-the oxidant mixture that is used for the flame plating of detonation rifle | UNION CARBIDE CORP (US) | 1989-05-03 | — | — | CN | claimed |
| CN-88100923-A | Piperazine derivatives and preparation method thereof | — | 1988-09-28 | — | — | CN | claimed |
| CN-87107279-A | Process for the carbonylation of acetylenically unsaturated compounds | — | 1988-06-15 | — | — | CN | claimed |
| CN-87104499-A | Novel alginic acid esters | — | 1988-04-06 | — | — | CN | claimed |
| CN-87103504-A | Heterocyclic carboxamide | — | 1987-12-09 | — | — | CN | claimed |
| CN-85104166-A | Preparation of new medicine and its preparation | — | 1986-11-26 | — | — | CN | claimed |
| US-4028384-A | HYDROSILYLATION WITH A HYDROGEN SILANE, PLATINUM COMPLEX CATALYST | DYNAMIT NOBEL AKTIENGESELLSCHAFT (DT) | 1977-06-07 | — | — | US | claimed |