Known targets — ChEMBL curated mechanism
ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3
The experimentally established mechanism targets of Dipivefrin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 6/20 | 0.84 |
| ▸ | ADRA2A known ✓ | P08913 | 4/20 | 0.42 |
| ▸ | ADRA2C known ✓ | P18825 | 4/20 | 0.42 |
| ▸ | ADRB1 known ✓ | P08588 | 3/20 | 0.42 |
| ▸ | ADRB3 known ✓ | P13945 | 3/20 | 0.42 |
| ▸ | ADRA2B known ✓ | P18089 | 3/20 | 0.42 |
| ▸ | ADRA1A known ✓ | P35348 | 3/20 | 0.42 |
| ▸ | ADRA1B known ✓ | P35368 | 2/20 | 0.42 |
| ▸ | ADRA1D known ✓ | P25100 | 1/20 | 0.42 |
| ▸ | HIF1A | Q16665 | 6/20 | 0.86 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.86 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.86 |
| ▸ | LMNA | P02545 | 2/20 | 0.86 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.42 |
| ▸ | MAPT | P10636 | 3/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 3/20 | 0.42 |
| ▸ | DRD1 | P21728 | 3/20 | 0.42 |
| ▸ | DRD3 | P35462 | 3/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dipivefrin SCHEMBL24713 | 0.93 | HIF1A (1.00) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| Dipivefrin SCHEMBL29710905 | 0.93 | HIF1A (1.00) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| Dipivefrin SCHEMBL20673238 | 0.93 | HIF1A (1.00) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| Dipivefrin SCHEMBL24714 | 0.93 | HIF1A (1.00) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| Dipivefrin SCHEMBL5275338 | 0.91 | ADRB2 (1.00) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| Dipivefrin SCHEMBL41350 | 0.91 | ADRB2 (1.00) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| Dipivefrin SCHEMBL41351 | 0.91 | ADRB2 (1.00) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| Dipivefrin SCHEMBL8071336 | 0.91 | ADRB2 (1.00) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| Dipivefrin SCHEMBL18687014 | 0.91 | ADRB2 (1.00) | HIF1AALDH1A1CYP3A4LMNAADRB2 | |
| Dipivefrin SCHEMBL3053588 | 0.90 | HIF1A (0.95) | HIF1AALDH1A1CYP3A4LMNAADRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5955546-A | COATING POLYPROPYLENE OR ETHYLENE/ALPHA-OLEFIN COPOLYMER HAVING A PRIMARY POLYOLEFIN SEGMENT LENGTH WITHIN A RANGE OF ABSOLUTE VALUE OF FROM ABOUT 4.2 TO ABOUT 8.8, WITH AT LEAST ONE MODIFYING POLYOLEFIN COMPRISING A COPOLYMER OF ETHYLENE | REGENTS OF THE UNIVERSITY OF MINNESOTA | 1999-09-21 | — | — | US | disclosed |
| US-5710219-A | Miscible polyolefin blends | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1998-01-20 | — | — | US | disclosed |
| US-5654364-A | Miscible blend of polyolefin and polyolefin block copolymer | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1997-08-05 | — | — | US | disclosed |
| US-5571864-A | POLYPROPYLENE BLENDED WITH ETHYLENE OR OLEFIN POLYMER OR BLOCK POLYMER | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1996-11-05 | — | — | US | disclosed |
| EP-0620251-A2 | Miscible polyolefin blends | REGENTS OF THE UNIVERSITY OF MINNESOTA (US) | 1994-10-19 | — | — | EP | disclosed |