Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CHRNB2 | P17787 | 4/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 4/20 | 0.46 |
| ▸ | CHRNA7 | P36544 | 3/20 | 0.45 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.45 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
| ▸ | PRMT6 | Q96LA8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19593180 | 0.81 | CHRNB2 (0.50) | CYP2D6CYP1A2CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL10843187 | 0.79 | CHRNA7 (0.52) | CYP2D6CYP1A2CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL27982323 | 0.79 | CHRNA7 (0.52) | CYP2D6CYP1A2CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL28017048 | 0.78 | NAPRT (0.47) | CYP2D6CYP1A2CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL4430706 | 0.77 | MAOB (0.68) | CYP2D6MEN1KMT2AL3MBTL1 | |
| SCHEMBL10421646 | 0.76 | CHRNA7 (0.52) | CYP2D6CYP1A2CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL27533556 | 0.76 | NAPRT (0.48) | CYP2D6CYP1A2CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL6158142 | 0.76 | CYP1A2 (0.48) | CYP2D6CYP1A2CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL27533915 | 0.76 | NAPRT (0.48) | CYP2D6CYP1A2CHRNB2CHRNA4CHRNA7 | |
| SCHEMBL1582780 | 0.75 | CHRNB2 (0.55) | CYP2D6CYP1A2CHRNB2CHRNA4CHRNA7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090227562-A1 | Combination of a Selective Noradrenaline Reuptake Unhibitor and a PDEV Inhibitor | PFIZER INC. (US) | 2009-09-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090227562-A1 | Combination of a Selective Noradrenaline Reuptake Unhibitor and a PDEV Inhibitor | PDE4A, PDE12, PDE4B | CYP2D6 502/4885CYP1A2 560/4885CHRNB2 96/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.