Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
| ▸ | BCHE | P06276 | 5/20 | 0.43 |
| ▸ | KDM2B | Q8NHM5 | 2/20 | 0.42 |
| ▸ | ERN1 | O75460 | 1/20 | 0.40 |
| ▸ | OTUD7B | Q6GQQ9 | 3/20 | 0.40 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.37 |
| ▸ | FYN | P06241 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4136371 | 0.90 | HRH3 (0.52) | HRH3BCHEKDM2BERN1OTUD7B | |
| SCHEMBL4136377 | 0.90 | HRH3 (0.52) | HRH3BCHEKDM2BERN1OTUD7B | |
| SCHEMBL4148572 | 0.83 | AKR1C3 (0.43) | HRH3BCHEERN1OTUD7BPDK2 | |
| SCHEMBL4142089 | 0.82 | HRH3 (0.42) | HRH3ERN1OTUD7BPDK2KEAP1 | |
| SCHEMBL4141043 | 0.80 | KDM2B (0.38) | KDM2BUSP30 | |
| SCHEMBL4141092 | 0.80 | BCHE (0.44) | HRH3BCHEMCHR1 | |
| SCHEMBL4143084 | 0.80 | KCNH2 (0.47) | HRH3KDM2BOTUD7BMCHR1 | |
| SCHEMBL4135208 | 0.80 | KEAP1 (0.39) | HRH3BCHEERN1OTUD7BPDK2 | |
| SCHEMBL4136604 | 0.80 | KDM2B (0.42) | HRH3KDM2BUSP30 | |
| SCHEMBL4141778 | 0.79 | HRH3 (0.41) | HRH3BCHEMCHR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | MCHARDY STANTON FURST | 2009-06-25 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090163482-A1 | TETRALINES ANTAGONISTS OF THE H-3 RECEPTOR | HRH3, HRH4, HRH1 | HRH3 1/4885BCHE 573/4885KDM2B 3965/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.