Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 7/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | GRIN2A | Q12879 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 3/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | PDE1A | P54750 | 1/20 | 0.32 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.32 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 2/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8032549 | 0.83 | PDE5A (0.36) | PDE5APDE3APDE3BKMT2APDE1A | |
| SCHEMBL4130410 | 0.80 | PARP1 (0.34) | KMT2AALDH1A1LMNAGRIN2AMEN1 | |
| SCHEMBL4132769 | 0.77 | PDE5A (0.42) | PDE5APDE3APDE3BKMT2AALDH1A1 | |
| SCHEMBL4125201 | 0.77 | PDE5A (0.36) | PDE5APDE3APDE3BKMT2AALDH1A1 | |
| SCHEMBL4126072 | 0.76 | PDE5A (0.42) | PDE5APDE3APDE3BKMT2AALDH1A1 | |
| SCHEMBL4117755 | 0.76 | KDM4E (0.41) | PDE5APDE3APDE3BMDM2KMT2A | |
| SCHEMBL4898303 | 0.76 | PDE5A (0.48) | PDE5APDE3APDE3BKMT2AALDH1A1 | |
| SCHEMBL8049072 | 0.76 | PDE5A (0.48) | PDE5APDE3APDE3BKMT2AALDH1A1 | |
| SCHEMBL4136868 | 0.73 | PDE5A (0.44) | PDE5APDE3APDE3BKMT2AALDH1A1 | |
| SCHEMBL8037857 | 0.73 | PDE5A (0.42) | PDE5APDE3APDE3BKMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071706-A1 | PYRAZOLEPYRIMIDINE COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |