Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 6/20 | 0.36 |
| ▸ | PDE6C | P51160 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.34 |
| ▸ | HPGD | P15428 | 3/20 | 0.34 |
| ▸ | USP2 | O75604 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.33 |
| ▸ | TSHR | P16473 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.33 |
| ▸ | GAA | P10253 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.32 |
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.32 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.32 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.32 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.31 |
| ▸ | PDE9A | O76083 | 2/20 | 0.31 |
| ▸ | PDE1C | Q14123 | 2/20 | 0.31 |
| ▸ | CASP1 | P29466 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4123024 | 0.78 | ALDH1A1 (0.36) | PDE5APDE6CKDM4EALDH1A1HPGD | |
| SCHEMBL8041296 | 0.78 | PDE5A (0.48) | PDE5APDE6CALDH1A1HPGDHSD17B10 | |
| SCHEMBL8031553 | 0.77 | KDM4E (0.34) | KDM4EALDH1A1HPGDUSP2HSD17B10 | |
| SCHEMBL4136313 | 0.77 | PDE5A (0.36) | PDE5AKDM4EALDH1A1HPGDTSHR | |
| SCHEMBL8049072 | 0.76 | PDE5A (0.48) | PDE5APDE6CALDH1A1HPGDPDE3B | |
| SCHEMBL8047602 | 0.75 | PDE5A (0.38) | PDE5APDE6CPDE3BPDE3A | |
| SCHEMBL8045595 | 0.75 | PDE5A (0.41) | PDE5APDE6CPDE4BPDE7APDE3B | |
| SCHEMBL8032549 | 0.75 | PDE5A (0.36) | PDE5APDE6CPDE4BPDE7APDE3B | |
| SCHEMBL8051166 | 0.73 | PDE5A (0.45) | PDE5APDE6CALDH1A1HPGDPDE4B | |
| SCHEMBL8047604 | 0.72 | PDE5A (0.42) | PDE5APDE6CALDH1A1HPGDPDE3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |
| WO-2009071707-A1 | NOVEL COMPOUNDS USEFUL FOR THE TREATMENT OF DEGENERATIVE & INFLAMMATORY DISEASES | GALAPAGOS NV (BE) | 2009-06-11 | — | — | WO | disclosed |