SCHEMBL4137074

SCHEMBL4137074

Cc1ccccc1-c1ccc(C=C2SC(Nc3ccc(C(Br)C(=O)O)c(F)c3)=NC2=O)cc1

nearest known ligand 0.36

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
ALOX5 P09917 15/20 0.36
SLC1A3 P43003 1/20 0.34
SLC1A2 P43004 1/20 0.34
SLC1A1 P43005 1/20 0.34
CISD1 Q9NZ45 1/20 0.34
POLB P06746 1/20 0.32
MAPT P10636 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4143591 0.84 MAOA (0.43) ALOX5CISD1
SCHEMBL4143594 0.84 MAOA (0.43) ALOX5CISD1
SCHEMBL4140156 0.78 HDAC1 (0.32) ALOX5CISD1MAPT
SCHEMBL4140153 0.78 HDAC1 (0.32) ALOX5CISD1MAPT
SCHEMBL4128820 0.77 KMT2A (0.47) ALOX5CISD1POLBMAPT
SCHEMBL4128816 0.77 KMT2A (0.47) ALOX5CISD1POLBMAPT
SCHEMBL4133274 0.77 MEN1 (0.41) ALOX5CISD1POLBMAPT
SCHEMBL4133272 0.77 MEN1 (0.41) ALOX5CISD1POLBMAPT
SCHEMBL4128197 0.76 ALOX5 (0.41) ALOX5POLBMAPT
SCHEMBL4128194 0.76 ALOX5 (0.41) ALOX5POLBMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors TORRENT PHARMACEUTICALS LIMITED (IN) 2009-04-02 US claimed
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors TORRENT PHARMACEUTICALS LIMITED (IN) 2009-04-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090088432-A1 Thiazolinones and Oxazolinones and their Use as Ptp1b Inhibitors PTPRF, PTPA, PTPRJ ALOX5 3505/4885SLC1A3 3975/4885SLC1A2 3764/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.