Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 4/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.51 |
| ▸ | NAAA | Q02083 | 4/20 | 0.43 |
| ▸ | NMT1 | P30419 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | ABL2 | P42684 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | GNRHR | P30968 | 1/20 | 0.39 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2E1 | P05181 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.39 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4137350 | 1.00 | KCNH2 (0.51) | KCNH2SLC6A2SLC6A4SLC6A3NAAA | |
| SCHEMBL4127012 | 0.90 | SLC6A2 (0.49) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4127003 | 0.90 | SLC6A2 (0.49) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4124171 | 0.89 | SLC6A2 (0.54) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4124176 | 0.89 | SLC6A2 (0.54) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4142178 | 0.88 | SLC6A2 (0.54) | KCNH2SLC6A2SLC6A4SLC6A3NAAA | |
| SCHEMBL4142167 | 0.88 | SLC6A2 (0.54) | KCNH2SLC6A2SLC6A4SLC6A3NAAA | |
| SCHEMBL4124497 | 0.88 | SLC6A4 (0.49) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4124491 | 0.88 | SLC6A4 (0.49) | KCNH2SLC6A2SLC6A4SLC6A3 | |
| SCHEMBL4145171 | 0.87 | SLC6A2 (0.50) | KCNH2SLC6A2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215857-A1 | Therapeutic Pyrrolidines | PFIZER PRODUCTS INC. (US) | 2009-08-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215857-A1 | Therapeutic Pyrrolidines | OPRL1, HTR5A, OPRD1 | KCNH2 673/4885SLC6A2 28/4885SLC6A4 18/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.