SCHEMBL4137527

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

	Compound	similarity	top predicted	shared targets
	SCHEMBL4137530	1.00	KDR (0.39)	KDRFNTAFNTBCHEK1CDK4
	SCHEMBL4136045	0.90	TUBB4A (0.38)	KDRCHEK1CDK4CCNA2CCND1
	SCHEMBL4144227	0.90	NPC1 (0.44)	MAOBTRPA1MAOAALDH1A1MAPT
	SCHEMBL4144222	0.90	NPC1 (0.44)	MAOBTRPA1MAOAALDH1A1MAPT
	SCHEMBL4136051	0.90	TUBB4A (0.38)	KDRCHEK1CDK4CCNA2CCND1
	SCHEMBL4145366	0.90	KDR (0.44)	KDRCHEK1CDK4CCND1CCND3
	SCHEMBL4145369	0.90	KDR (0.44)	KDRCHEK1CDK4CCND1CCND3
	SCHEMBL4137384	0.89	NFE2L2 (0.38)	KDRCHEK1PTGS2TRPA1ALDH1A1
	SCHEMBL4137389	0.89	NFE2L2 (0.38)	KDRCHEK1PTGS2TRPA1ALDH1A1
	SCHEMBL4144584	0.89	PIM1 (0.40)	KDRCHEK1CDK4CCNA2CCND1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.