Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Penbutolol. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB2 known ✓ | P07550 | 7/20 | 0.56 |
| ▸ | ADRB1 known ✓ | P08588 | 5/20 | 0.56 |
| ▸ | HTR1A | P08908 | 5/20 | 0.89 |
| ▸ | ADRA2A | P08913 | 3/20 | 0.89 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.89 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.89 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.89 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.89 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.89 |
| ▸ | USP2 | O75604 | 1/20 | 0.89 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.89 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.89 |
| ▸ | DRD1 | P21728 | 1/20 | 0.89 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.89 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.89 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.89 |
| ▸ | DRD3 | P35462 | 1/20 | 0.89 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.89 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Penbutolol SCHEMBL41406 | 1.00 | HTR1A (0.89) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL41407 | 1.00 | HTR1A (0.89) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL30872868 | 0.94 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL31572112 | 0.94 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL49358 | 0.94 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL29483932 | 0.94 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL41408 | 0.94 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL1652319 | 0.94 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL6511962 | 0.94 | HTR1A (1.00) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A | |
| Penbutolol SCHEMBL7529895 | 0.93 | HTR1A (0.98) | HTR1AADRA2ASLC6A4CYP2D6ADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 2239 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4615449-A1 | METHOD TO PREVENT AND TREAT DIABETIC RETINOPATHY BY CALCIUM CHANNEL BLOCKERS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS, AND ANGIOTENSIN RECEPTOR BLOCKERS | Weinberg, Assa (US) | 2025-09-17 | — | — | EP | claimed |
| US-20250262195-A1 | METHOD TO PREVENT AND TREAT DIABETIC RETINOPATHY BY CALCIUM CHANNEL BLOCKERS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS, AND ANGIOTENSIN RECEPTOR BLOCKERS | WEINBERG ASSA (US) | 2025-08-21 | — | — | US | claimed |
| EP-4598526-A1 | METHOD TO PREVENT AND TREAT GLAUCOMA BY CALCIUM CHANNEL BLOCKERS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS, AND ANGIOTENSIN RECEPTOR BLOCKERS | Weinberg, Assa (US) | 2025-08-13 | — | — | EP | claimed |
| US-20250228831-A1 | METHOD TO PREVENT AND TREAT GLAUCOMA BY CALCIUM CHANNEL BLOCKERS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS, AND ANGIOTENSIN RECEPTOR BLOCKERS | WEINBERG ASSA (US) | 2025-07-17 | — | — | US | claimed |
| WO-2024102328-A1 | METHOD TO PREVENT AND TREAT DIABETIC RETINOPATHY BY CALCIUM CHANNEL BLOCKERS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS, AND ANGIOTENSIN RECEPTOR BLOCKERS | WEINBERG ASSA (US) | 2024-05-16 | — | — | WO | claimed |
| WO-2024076697-A1 | METHOD TO PREVENT AND TREAT GLAUCOMA BY CALCIUM CHANNEL BLOCKERS, ANGIOTENSIN CONVERTING ENZYME INHIBITORS, AND ANGIOTENSIN RECEPTOR BLOCKERS | WEINBERG ASSA (US) | 2024-04-11 | — | — | WO | claimed |
| EP-3737676-B1 | ACETAL COMPOUNDS AND THERAPEUTIC USES THEREOF | LIGAND PHARM INC (US) | 2024-03-06 | — | — | EP | claimed |
| US-20230091848-A1 | DISEASE DETECTION AND TREATMENT BASED ON PHENYLACETYL GLUTAMINE LEVELS | THE CLEVELAND CLINIC FOUNDATION | 2023-03-23 | — | — | US | claimed |
| US-20230017661-A1 | COMPOSITIONS AND MODULAR NANO- AND MICROPARTICLES FOR THE DELIVERY OF VARIOUS AGENTS AND USE THEREOF | VERI NANO INC. (US) | 2023-01-19 | — | — | US | claimed |
| US-20230003721-A1 | MITOTHERAPEUTICS FOR THE TREATMENT OF BRAIN DISORDERS | THE UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. | 2023-01-05 | — | — | US | claimed |
| EP-0312283-A2 | Di-or tripeptide renin inhibitors containing lactam conformational restrictions in ACHPA | MERCK & CO. INC. (US) | 1989-04-19 | — | — | EP | claimed |
| US-4782043-A | HYPOTENSIVES | MERCK & CO., INC. (US) | 1988-11-01 | — | — | US | claimed |
| EP-0278158-A2 | Renin inhibitors containing phenylalanyl-histidine replacements | MERCK & CO. INC. (US) | 1988-08-17 | — | — | EP | claimed |
| EP-0273696-A2 | Renin inhibitors containing histidine replacements | MERCK & CO. INC. (US) | 1988-07-06 | — | — | EP | claimed |
| EP-0209897-A2 | Peptide enzyme inhibitors | MERCK & CO. INC. (US) | 1987-01-28 | — | — | EP | claimed |
| EP-0163237-A2 | Di- and tri-peptidal renin inhibitors | MERCK & CO. INC. (US) | 1985-12-04 | — | — | EP | claimed |
| EP-0157409-A2 | Renin inhibitors containing 2-substituted statine | MERCK & CO. INC. (US) | 1985-10-09 | — | — | EP | claimed |
| EP-0156318-A2 | C-terminal amide cyclic renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| EP-0156322-A2 | Renin inhibitors containing peptide isosteres | MERCK & CO. INC. (US) | 1985-10-02 | — | — | EP | claimed |
| EP-0129189-A2 | Renin inhibitors containing a C-terminal amide cycle and compositions and combinations containing the same | MERCK & CO. INC. (US) | 1984-12-27 | — | — | EP | claimed |