Sugi Predict

Sugi Predict / Compounds / SCHEMBL4144271

SCHEMBL4144271

SCHEMBL4144271

Cc1c(-c2ccc(Cl)cc2)[nH]c2ccc(OCc3ccccc3)cc12

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ TRPM8 Q7Z2W7 1/20 0.52
▸ KDM4E B2RXH2 2/20 0.49
▸ MAPT P10636 2/20 0.49
▸ ALDH1A1 P00352 1/20 0.49
▸ GAA P10253 1/20 0.49
▸ SMN1; SMN2 Q16637 1/20 0.49
▸ NPSR1 Q6W5P4 1/20 0.49
▸ MAOB P27338 3/20 0.49
▸ MAOA P21397 3/20 0.49
▸ LMNA P02545 1/20 0.48
▸ HPGD P15428 1/20 0.48
▸ HTT P42858 1/20 0.48
▸ HSD17B10 Q99714 1/20 0.48
▸ CTSV O60911 3/20 0.48
▸ CTSL P07711 3/20 0.48
▸ NR1I2 O75469 1/20 0.47
▸ NSD2 O96028 1/20 0.47
▸ AS3MT Q9HBK9 1/20 0.47
▸ GABRA1 P14867 1/20 0.46
▸ GABRG2 P18507 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL102598 0.93 TRPM8 (0.56) TRPM8KDM4EMAPTALDH1A1GAA
SCHEMBL29652545 0.93 TRPM8 (0.56) TRPM8KDM4EMAPTALDH1A1GAA
SCHEMBL4151637 0.91 TRPM8 (0.57) TRPM8KDM4EMAPTALDH1A1GAA
SCHEMBL4156633 0.90 TRPM8 (0.54) TRPM8KDM4EMAPTALDH1A1GAA
SCHEMBL4155146 0.89 TRPM8 (0.53) TRPM8KDM4EMAPTALDH1A1GAA
SCHEMBL8610000 0.88 CTSV (0.53) TRPM8KDM4EMAPTALDH1A1GAA
SCHEMBL4158966 0.88 TRPM8 (0.52) TRPM8KDM4EMAPTALDH1A1GAA
SCHEMBL19949651 0.88 TRPM8 (0.52) TRPM8KDM4EMAPTALDH1A1GAA
SCHEMBL12585390 0.85 TRPM8 (0.48) TRPM8KDM4EMAPTALDH1A1GAA
SCHEMBL4155076 0.85 TRPM8 (0.54) TRPM8KDM4EMAPTALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3512842-B1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ARVINAS INC (US) 2024-01-17 — — EP disclosed
US-11584743-B2 Indole derivatives as estrogen receptor degraders ARVINAS OPERATIONS, INC. (US) 2023-02-21 — — US disclosed
US-11584743-B2 Indole derivatives as estrogen receptor degraders ARVINAS OPERATIONS, INC. (US) 2023-02-21 — — US disclosed
US-20210040081-A1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS Arvinas, Inc. 2021-02-11 — — US disclosed
US-20210040081-A1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS Arvinas, Inc. 2021-02-11 — — US disclosed
US-10865202-B2 Indole derivatives as estrogen receptor degraders ARVINAS OPERATIONS, INC. (US) 2020-12-15 — — US disclosed
US-10865202-B2 Indole derivatives as estrogen receptor degraders ARVINAS OPERATIONS, INC. (US) 2020-12-15 — — US disclosed
US-20190233408-A1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS Arvinas, Inc. 2019-08-01 — — US disclosed
US-20190233408-A1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS Arvinas, Inc. 2019-08-01 — — US disclosed
EP-3512842-A1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS Arvinas, Inc. (US) 2019-07-24 — — EP disclosed
US-6291451-B1 USEFUL IN THE TREATMENT OR INHIBITION OF BREAST CANCER. AMERICAN HOME PRODUCTS CORPORATION 2001-09-18 — — US disclosed
US-20010021719-A1 2-phenyl-1- [4- (2-aminoethoxy) - benzyl] - indoles as estrogenic agents WYETH 2001-09-13 — — US disclosed
US-6232307-B1 2-PHENYL-1-(4-(2-AMINOETHOXY)-BENZYL)-INDOLE COMPOUNDS USEFUL AS ESTROGENIC AGENTS AMERICAN HOME PRODUCTS CORPORATION 2001-05-15 — — US disclosed
US-6225308-B1 2-PHENYL-1-(4-(2-AMINOETHOXY)-BENZYL)-INDOLE COMPOUNDS WHICH ARE USEFUL AS ESTROGENIC AGENTS AMERICAN HOME PRODUCTS CORPORATION 2001-05-01 — — US disclosed
EP-1076558-A1 2-PHENYL-1-[-(2-AMINOETHOXY)-BENZYL -INDOLE IN COMBINATION WITH ESTROGENS AMERICAN HOME PRODUCTS CORPORATION (US) 2001-02-21 — — EP disclosed
US-6127404-A 2-PHENYL-1-(4-(2-AMINOETHOXY)-BENZYL)INDOLE COMPOUNDS USEFUL AS ESTROGEN AGONISTS/ANTAGONISTS; OSTEOPOROSIS; ANTICHOLESTEROL AGENTS AMERICAN HOME PRODUCTS CORPORATION (US) 2000-10-03 — — US disclosed
US-5998402-A OSTEOPOROSIS; CARDIOVASCULAR DISORDERS; ANTICANCER AGENTS;POSTMEMOPAUSE THERAPY AMERICAN HOME PRODUCTS CORPORATION (US) 1999-12-07 — — US disclosed
WO-1999059581-A1 2-PHENYL-1-[4-(2-AMINOETHOXY)-BENZYL]-INDOLE IN COMBINATION WITH ESTROGENS AMERICAN HOME PRODUCTS CORPORATION (US) 1999-11-25 — — WO disclosed
CN-1170719-A Estrogenic agents AMERICAN HOME PROD (US) 1998-01-21 — — CN disclosed
EP-0802183-A1 Estrogenic agents AMERICAN HOME PRODUCTS CORPORATION (US) 1997-10-22 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20010021719-A1 2-phenyl-1- [4- (2-aminoethoxy) - benzyl] - indoles as estrogenic agents ESR1, ESR2, GPER1 TRPM8 3089/4885KDM4E 456/4885MAPT 1167/4885
US-20210040081-A1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ESR1, GPER1, ESR2 TRPM8 319/4885KDM4E 676/4885MAPT 2535/4885
US-10865202-B2 Indole derivatives as estrogen receptor degraders ESR1, GPER1, ESR2 TRPM8 319/4885KDM4E 676/4885MAPT 2535/4885
US-11584743-B2 Indole derivatives as estrogen receptor degraders ESR1, GPER1, ESR2 TRPM8 319/4885KDM4E 676/4885MAPT 2535/4885
US-20190233408-A1 INDOLE DERIVATIVES AS ESTROGEN RECEPTOR DEGRADERS ESR1, GPER1, ESR2 TRPM8 319/4885KDM4E 676/4885MAPT 2535/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.