Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.73 |
| ▸ | ABCG2 | Q9UNQ0 | 3/20 | 0.73 |
| ▸ | BCHE | P06276 | 1/20 | 0.70 |
| ▸ | ACHE | P22303 | 1/20 | 0.70 |
| ▸ | PPARG | P37231 | 2/20 | 0.66 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.63 |
| ▸ | CREB1 | P16220 | 1/20 | 0.55 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.55 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.55 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.55 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.54 |
| ▸ | RET | P07949 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13741293 | 0.87 | L3MBTL1 (0.71) | L3MBTL1ABCG2BCHEACHEPPARG | |
| SCHEMBL14048682 | 0.87 | MAPT (0.78) | L3MBTL1ABCG2BCHEACHEMAPT | |
| SCHEMBL18526951 | 0.86 | ABCG2 (0.65) | L3MBTL1ABCG2BCHEACHEPPARG | |
| SCHEMBL4268322 | 0.85 | L3MBTL1 (1.00) | L3MBTL1ABCG2BCHEACHEPPARG | |
| SCHEMBL13751451 | 0.84 | ABCG2 (0.61) | L3MBTL1ABCG2ABCB1CYP2C9CYP2C19 | |
| SCHEMBL15232150 | 0.84 | ABCG2 (1.00) | L3MBTL1ABCG2BCHEACHEPPARG | |
| SCHEMBL15245959 | 0.84 | FLT3 (0.74) | ABCG2BCHEACHEMAPTABCB1 | |
| SCHEMBL24882669 | 0.82 | EGFR (0.78) | ABCG2PPARGMAPTABCB1CYP2C9 | |
| SCHEMBL5792042 | 0.82 | MAPT (0.91) | L3MBTL1ABCG2BCHEACHEPPARG | |
| SCHEMBL19267888 | 0.82 | L3MBTL1 (0.77) | L3MBTL1ABCG2BCHEACHEPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10208025-B2 | Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2019-02-19 | — | — | US | disclosed |
| US-9611256-B2 | Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-04-04 | — | — | US | disclosed |
| US-20170044141-A1 | ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS | THE HONG KONG POLYTECHNIC UNIVERSITY (HK) | 2017-02-16 | — | — | US | disclosed |
| US-20150011513-A1 | ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS | THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY (CA) | 2015-01-08 | — | — | US | disclosed |
| US-8710097-B2 | Flavonoid dimers and methods of making and using such | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2014-04-29 | — | — | US | disclosed |
| US-8710097-B2 | Flavonoid dimers and methods of making and using such | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2014-04-29 | — | — | US | disclosed |
| WO-2013127361-A1 | ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2013-09-06 | — | — | WO | disclosed |
| US-20090197943-A1 | Flavonoid Dimers and Methods of Making and Using Such | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2009-08-06 | — | — | US | disclosed |
| US-20090197943-A1 | Flavonoid Dimers and Methods of Making and Using Such | THE HONG KONG POLYTECHNIC UNIVERSITY (CN) | 2009-08-06 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170044141-A1 | ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS | ABCG2, ABCB1, ABCC1 | L3MBTL1 828/4885ABCG2 1/4885BCHE 3290/4885 |
| US-10208025-B2 | Alkyne-, azide- and triazole-containing flavonoids as modulators for multidrug resistance in cancers | ABCG2, ABCB1, ABCC1 | L3MBTL1 828/4885ABCG2 1/4885BCHE 3290/4885 |
| US-20150011513-A1 | ALKYNE-, AZIDE- AND TRIAZOLE-CONTAINING FLAVONOIDS AS MODULATORS FOR MULTIDRUG RESISTANCE IN CANCERS | ABCG2, ABCB1, ABCC1 | L3MBTL1 828/4885ABCG2 1/4885BCHE 3290/4885 |
| US-20090197943-A1 | Flavonoid Dimers and Methods of Making and Using Such | ABCB1, ABCC1, SLC47A2 | L3MBTL1 2490/4885ABCG2 6/4885BCHE 3126/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.