⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL15513956 | 0.97 | — | — | |
| Tetrahydrofuran SCHEMBL28130664 | 0.82 | ALDH1A1 (0.35) | — | |
| SCHEMBL7111335 | 0.77 | — | — | |
| SCHEMBL28675754 | 0.76 | ALDH1A1 (0.39) | — | |
| SCHEMBL11409673 | 0.75 | — | — | |
| SCHEMBL30421227 | 0.75 | LMNA (0.44) | — | |
| SCHEMBL17704771 | 0.73 | CHRM1 (0.36) | — | |
| SCHEMBL3448389 | 0.73 | CHRM1 (0.36) | — | |
| SCHEMBL28464174 | 0.73 | — | — | |
| SCHEMBL11679266 | 0.73 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 519 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119462458-A | Covalent inhibitor of targeted hCES A and preparation method and application thereof | 中国人民解放军海军军医大学 | 2025-02-18 | — | — | CN | claimed |
| CN-116926027-A | Alcohol dehydrogenase mutant and application thereof in synthesis of rivastigmine intermediate | 华中农业大学 | 2023-10-24 | — | — | CN | claimed |
| CN-109507345-B | Rivastigmine bitartrate intermediate and separation and determination method of impurities thereof | 万特制药(海南)有限公司 | 2022-08-05 | — | — | CN | claimed |
| CN-110668976-A | Rivastigmine optical isomeric intermediate and synthetic method of (R) -rivastigmine | 山东师范大学 | 2020-01-10 | — | — | CN | claimed |
| CN-110272358-A | A kind of preparation method of Rivastigmine citrate | 万邦德制药集团股份有限公司 | 2019-09-24 | — | — | CN | claimed |
| CN-109507345-A | The method of separating and assaying of rivastigmine intermediate and its impurity | 万特制药(海南)有限公司 | 2019-03-22 | — | — | CN | claimed |
| CN-108822000-A | A kind of method of reduction amination synthesis (S)-Rivastigmine | 山东师范大学 | 2018-11-16 | — | — | CN | claimed |
| CN-106565543-B | A kind of preparation method of rivastigmine-hydrogentartrate | 昆明源瑞制药有限公司 | 2018-06-22 | — | — | CN | claimed |
| CN-106565543-A | Preparation method of rivastigmine tartrate | 昆明源瑞制药有限公司 | 2017-04-19 | — | — | CN | claimed |
| EP-1856036-B1 | AN EFFICIENT METHOD FOR PREPARATION OF (S)-3-[(1-DIMETHYL AMINO)ETHYL]-PHENYL-N-ETHYL-N-METHYL-CARBAMATE | EMCURE PHARMACEUTICALS LTD (IN) | 2016-12-14 | — | — | EP | claimed |
| CN-102503858-A | Synthesis method of N-ethyl-N-methyl amido formyl chloride | TAICANG YUNTONG CHEMICAL FACTORY | 2012-06-20 | — | — | CN | claimed |
| CN-102285904-A | Method for preparing rivastigmine | — | 2011-12-21 | — | — | CN | claimed |
| US-8013181-B2 | Reacting S-(-)-[1-(3-hydroxyphenyl)ethyl]dimethylamine with N-ethyl-N-methyl carbamoyl chloride in the presence of an organic base | DR. REDDY'S LABORATORIES LIMITED (IN) | 2011-09-06 | — | — | US | claimed |
| CN-101823970-A | Synthetic method of rivastigmine and intermediates thereof | JIANGSU NHWA PHARMACEUTICAL CO LTD | 2010-09-08 | — | — | CN | claimed |
| CN-101643439-A | Method for preparing ethylmethylamino formyl chloride | ZHEJIANG JIUZHOU PHARMACEUTICA | 2010-02-10 | — | — | CN | claimed |
| US-20080255383-A1 | PREPARATION OF RIVASTIGMINE AND ITS SALTS | DR. REDDY'S LABORATORIES, INC. | 2008-10-16 | — | — | US | claimed |
| EP-1980552-A2 | A process for the preparation of rivastigmine or a salt thereof | Dr. Reddy's Laboratories Ltd. (IN) | 2008-10-15 | — | — | EP | claimed |
| EP-1856036-A1 | AN EFFICIENT METHOD FOR PREPARATION OF (S)-3-[(1-DIMETHYL AMINO)ETHYL]-PHENYL-N-ETHYL-N-METHYL-CARBAMATE | Emcure Pharmaceuticals Limited (IN) | 2007-11-21 | — | — | EP | claimed |
| WO-2006068386-A1 | SYNTHETIC METHOD OF PHENYLCARBAMATE DERIVATIVE | DONG KOOK PHARM. CO., LTD (KR) | 2006-06-29 | — | — | WO | claimed |
| WO-2006048720-A1 | AN EFFICIENT METHOD FOR PREPARATION OF (S)-3-[(1-DIMETHYL AMINO)ETHYL]-PHENYL-N-ETHYL-N-METHYL-CARBAMATE | EMCURE PHARMACEUTICALS LIMITED (IN) | 2006-05-11 | — | — | WO | claimed |