Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XDH | P47989 | 5/20 | 0.65 |
| ▸ | BACE1 | P56817 | 1/20 | 0.53 |
| ▸ | BRD4 | O60885 | 3/20 | 0.49 |
| ▸ | PDE5A | O76074 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.46 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | TLR4 | O00206 | 1/20 | 0.46 |
| ▸ | TLR3 | O15455 | 1/20 | 0.46 |
| ▸ | TLR5 | O60602 | 1/20 | 0.46 |
| ▸ | TLR2 | O60603 | 1/20 | 0.46 |
| ▸ | CAMK2B | Q13554 | 1/20 | 0.46 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.46 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.46 |
| ▸ | CAMK1 | Q14012 | 1/20 | 0.46 |
| ▸ | CAMK4 | Q16566 | 1/20 | 0.46 |
| ▸ | PNCK | Q6P2M8 | 1/20 | 0.46 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.46 |
| ▸ | CAMK1G | Q96NX5 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4149619 | 0.79 | XDH (1.00) | XDHBACE1 | |
| SCHEMBL4149108 | 0.77 | XDH (0.77) | XDHBACE1 | |
| SCHEMBL28514992 | 0.75 | ACHE (0.51) | BRD4PDE5ATLR4TLR3TLR5 | |
| SCHEMBL9905228 | 0.74 | BRD4 (0.52) | BRD4PDE5APDE4APDE4BPDE4C | |
| SCHEMBL4142212 | 0.73 | BACE1 (0.76) | XDHBACE1 | |
| SCHEMBL21885713 | 0.73 | XDH (0.61) | XDHBACE1 | |
| SCHEMBL4142364 | 0.73 | XDH (0.61) | XDHBACE1 | |
| SCHEMBL13851581 | 0.73 | POLB (0.63) | BRD4PDE5APDE4APDE4BPDE4C | |
| SCHEMBL8597102 | 0.72 | BRD4 (0.50) | BRD4TLR4TLR3TLR5TLR2 | |
| SCHEMBL8265140 | 0.72 | BACE1 (0.67) | XDHBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090221579-A1 | Substituted Amino-Compounds and Uses Thereof | ASTEX THERAPEUTICS (GB) | 2009-09-03 | — | — | US | disclosed |
| US-20090062282-A1 | Substituted Amino-Pyrimidones and Uses Thereof | ASTRAZENECA AB (SE) | 2009-03-05 | — | — | US | disclosed |
| CN-101084198-A | Substituted amino-pyrimidones and uses thereof | ASTRAZENECA AB (SE) | 2007-12-05 | — | — | CN | disclosed |
| CN-101084199-A | Substituted amino-compounds and uses thereof | ASTRAZENECA AB (SE) | 2007-12-05 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090221579-A1 | Substituted Amino-Compounds and Uses Thereof | APP, PSEN1, BACE1 | XDH 951/4885BACE1 3/4885BRD4 3927/4885 |
| US-20090062282-A1 | Substituted Amino-Pyrimidones and Uses Thereof | APP, PSEN1, PSEN2 | XDH 259/4885BACE1 4/4885BRD4 2822/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.