Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCA | P17252 | 1/20 | 0.37 |
| ▸ | MMP12 | P39900 | 1/20 | 0.37 |
| ▸ | MTHFD2 | P13995 | 2/20 | 0.33 |
| ▸ | MTHFD1 | P11586 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.32 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4146357 | 1.00 | PRKCA (0.37) | PRKCAMMP12MTHFD2MTHFD1ALDH1A1 | |
| SCHEMBL4156040 | 0.94 | PRKCA (0.38) | PRKCAMMP12MTHFD2ALDH1A1KDM4E | |
| SCHEMBL4156042 | 0.94 | PRKCA (0.38) | PRKCAMMP12MTHFD2ALDH1A1KDM4E | |
| SCHEMBL4152577 | 0.92 | ALDH1A1 (0.37) | ALDH1A1KDM4ELMNAMAPTTHRB | |
| SCHEMBL4152580 | 0.92 | ALDH1A1 (0.37) | ALDH1A1KDM4ELMNAMAPTTHRB | |
| SCHEMBL4155304 | 0.92 | PRKCA (0.37) | PRKCAMMP12SLC6A5PRMT5WDR77 | |
| SCHEMBL4155300 | 0.92 | PRKCA (0.37) | PRKCAMMP12SLC6A5PRMT5WDR77 | |
| SCHEMBL4149639 | 0.92 | PRKCA (0.39) | PRKCAMMP12CYP3A4KCNH2SCN5A | |
| SCHEMBL4152682 | 0.92 | PRKCA (0.39) | PRKCAMMP12CYP3A4KCNH2SCN5A | |
| SCHEMBL4151555 | 0.90 | PRKCA (0.39) | PRKCAMMP12SLC6A5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2009-05-28 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090136449-A1 | Tetracyclic Indole Derivatives as Antiviral Agents | IDO1, IDO2, ZC3HAV1 | PRKCA 4320/4885MMP12 3563/4885MTHFD2 4262/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.