Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.43 |
| ▸ | BRD4 | O60885 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 7/20 | 0.41 |
| ▸ | CDK7 | P50613 | 7/20 | 0.41 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | AKT1 | P31749 | 6/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 2/20 | 0.39 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.39 |
| ▸ | RPS6KA4 | O75676 | 2/20 | 0.39 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.39 |
| ▸ | PAK4 | O96013 | 2/20 | 0.39 |
| ▸ | CHEK2 | O96017 | 2/20 | 0.39 |
| ▸ | PRKCG | P05129 | 2/20 | 0.39 |
| ▸ | PIM1 | P11309 | 2/20 | 0.39 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.39 |
| ▸ | PRKACA | P17612 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL938434 | 0.83 | ROCK2 (0.43) | ROCK2BRD4CDK2CDK7KDM4E | |
| SCHEMBL938433 | 0.83 | ROCK2 (0.43) | ROCK2BRD4CDK2CDK7KDM4E | |
| SCHEMBL22191157 | 0.81 | PDE3B (0.44) | ROCK2CDK2CDK7PRMT5WDR77 | |
| SCHEMBL22191278 | 0.81 | PDE3B (0.44) | ROCK2CDK2CDK7PRMT5WDR77 | |
| SCHEMBL22191156 | 0.81 | PDE3B (0.44) | ROCK2CDK2CDK7PRMT5WDR77 | |
| SCHEMBL13554564 | 0.78 | ROCK2 (0.48) | ROCK2BRD4KDM4EALDH1A1ROCK1 | |
| SCHEMBL1753937 | 0.77 | F11 (0.71) | F11 | |
| SCHEMBL2105159 | 0.77 | F11 (0.71) | F11 | |
| SCHEMBL4158845 | 0.77 | ROCK2 (0.41) | ROCK2BRD4KDM4EALDH1A1PRKACA | |
| SCHEMBL1196662 | 0.76 | ROCK2 (0.48) | ROCK2KDM4EALDH1A1ROCK1F11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090181983-A1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL -MEYERS SQUIBB COMPANY | 2009-07-16 | — | — | US | claimed |
| US-20090181983-A1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | BRISTOL -MEYERS SQUIBB COMPANY | 2009-07-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090181983-A1 | SIX-MEMBERED HETEROCYCLES USEFUL AS SERINE PROTEASE INHIBITORS | TFPI, F11, F12 | ROCK2 653/4885BRD4 2366/4885CDK2 577/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.