SCHEMBL414892

SCHEMBL414892

FC(F)(F)Oc1ccc(C=NNc2cc(Nc3ccc(Cl)cc3)nc(-c3ccccc3)n2)cc1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CHRNA7 P36544 2/20 0.49
FFAR1 O14842 1/20 0.47
MAPT P10636 6/20 0.47
MEN1 O00255 4/20 0.47
KMT2A Q03164 4/20 0.47
CYP1A2 P05177 3/20 0.47
ALDH1A1 P00352 2/20 0.47
CYP2C9 P11712 1/20 0.47
NPC1 O15118 2/20 0.47
GAA P10253 2/20 0.47
RAB9A P51151 2/20 0.47
MITF O75030 1/20 0.47
ALOX5 P09917 1/20 0.41
CYP3A4 P08684 2/20 0.41
CYP2C19 P33261 2/20 0.41
HTT P42858 1/20 0.41
POLB P06746 1/20 0.41
CYP2D6 P10635 1/20 0.41
NPSR1 Q6W5P4 1/20 0.41
CA12 O43570 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL414891 1.00 CHRNA7 (0.49) CHRNA7FFAR1MAPTMEN1KMT2A
SCHEMBL10242542 1.00 CHRNA7 (0.49) CHRNA7FFAR1MAPTMEN1KMT2A
SCHEMBL416437 0.85 CHRNA7 (0.61) CHRNA7MAPTMEN1KMT2ANPC1
SCHEMBL17836749 0.85 CHRNA7 (0.61) CHRNA7MAPTMEN1KMT2ANPC1
SCHEMBL413708 0.85 CHRNA7 (0.61) CHRNA7MAPTMEN1KMT2ANPC1
SCHEMBL10240830 0.85 MAPT (0.50) CHRNA7MAPTMEN1KMT2AALDH1A1
SCHEMBL415579 0.85 MAPT (0.50) CHRNA7MAPTMEN1KMT2AALDH1A1
SCHEMBL418073 0.85 MAPT (0.50) CHRNA7MAPTMEN1KMT2AALDH1A1
SCHEMBL416609 0.85 CHRNA7 (0.48) CHRNA7MAPTMEN1KMT2AALDH1A1
SCHEMBL10240840 0.85 CHRNA7 (0.48) CHRNA7MAPTMEN1KMT2AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-106035343-A Insecticidal triazines and pyrimidines 韦斯塔隆公司 2016-10-26 CN claimed
EP-2595965-B1 INSECTICIDAL TRIAZINES AND PYRIMIDINES VESTARON CORP (US) 2016-06-22 EP claimed
US-9321735-B2 Insecticidal triazines and pyrimidines Vestaron Corporation (US) 2016-04-26 US claimed
US-8785630-B2 Insecticidal triazines and pyrimidines Vestaron Corporation (US) 2014-07-22 US claimed
US-20130267705-A1 Insecticidal Triazines and Pyrimidines Vestaron Corporation (US) 2013-10-10 US claimed
US-20130150365-A1 Insecticidal Triazines and Pyrimidines Vestaron Corporation (US) 2013-06-13 US claimed
EP-2595965-A1 INSECTICIDAL TRIAZINES AND PYRIMIDINES Vestaron Corporation (US) 2013-05-29 EP claimed
CN-103052628-A Triazine and pyrimidine insecticides VESTARON CORP 2013-04-17 CN claimed
US-20120022066-A1 Insecticidal Triazines and Pyrimidines Vestaron Corporation (US) 2012-01-26 US claimed
WO-2012012528-A1 INSECTICIDAL TRIAZINES AND PYRIMIDINES Vestaron Corporation (US) 2012-01-26 WO claimed
EP-2595965-B1 INSECTICIDAL TRIAZINES AND PYRIMIDINES VESTARON CORP (US) 2016-06-22 EP disclosed
CN-103052628-B Triazine and pyrimidine insecticides VESTARON CORP. (US) 2016-05-18 CN disclosed
US-9321735-B2 Insecticidal triazines and pyrimidines Vestaron Corporation (US) 2016-04-26 US disclosed
US-9321735-B2 Insecticidal triazines and pyrimidines Vestaron Corporation (US) 2016-04-26 US disclosed
US-8785630-B2 Insecticidal triazines and pyrimidines Vestaron Corporation (US) 2014-07-22 US disclosed
US-8389718-B2 Insecticidal triazines and pyrimidines Vestaron Corporation (US) 2013-03-05 US disclosed
US-8389718-B2 Insecticidal triazines and pyrimidines Vestaron Corporation (US) 2013-03-05 US disclosed
US-20120022066-A1 Insecticidal Triazines and Pyrimidines Vestaron Corporation (US) 2012-01-26 US disclosed
US-20120022066-A1 Insecticidal Triazines and Pyrimidines Vestaron Corporation (US) 2012-01-26 US disclosed
WO-2012012528-A1 INSECTICIDAL TRIAZINES AND PYRIMIDINES Vestaron Corporation (US) 2012-01-26 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130150365-A1 Insecticidal Triazines and Pyrimidines TYMS, TYMP, DHX15 CHRNA7 2075/4885FFAR1 4451/4885MAPT 3000/4885
US-20120022066-A1 Insecticidal Triazines and Pyrimidines TYMS, TYMP, DHX15 CHRNA7 2075/4885FFAR1 4451/4885MAPT 3000/4885
US-20130267705-A1 Insecticidal Triazines and Pyrimidines TYMS, TYMP, DHX15 CHRNA7 2075/4885FFAR1 4451/4885MAPT 3000/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.