Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PARP1 | P09874 | 4/20 | 0.49 |
| ▸ | MGAM | O43451 | 8/20 | 0.42 |
| ▸ | GAA | P10253 | 8/20 | 0.42 |
| ▸ | SI | P14410 | 8/20 | 0.42 |
| ▸ | MGAM2 | Q2M2H8 | 8/20 | 0.42 |
| ▸ | PTGES | O14684 | 1/20 | 0.41 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.37 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.35 |
| ▸ | TRPA1 | O75762 | 2/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | ATR | Q13535 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL558190 | 0.77 | AXL (0.47) | PARP1TRPM8AXLTRPA1TRPV1 | |
| SCHEMBL1812287 | 0.75 | NPC1 (0.54) | GAA | |
| SCHEMBL8818583 | 0.70 | PARP1 (0.63) | PARP1MGAMGAASIMGAM2 | |
| SCHEMBL505343 | 0.70 | DHODH (0.57) | PARP1MGAMGAASIMGAM2 | |
| SCHEMBL183317 | 0.69 | METAP2 (0.48) | NPY5R | |
| SCHEMBL12934190 | 0.68 | PARP1 (0.50) | PARP1GAAPTGESNPY5RAXL | |
| SCHEMBL31027935 | 0.68 | HDAC6 (0.58) | PARP1MGAMGAASIMGAM2 | |
| SCHEMBL22452437 | 0.68 | HDAC6 (0.58) | PARP1MGAMGAASIMGAM2 | |
| SCHEMBL124272 | 0.68 | CBFB (0.68) | — | |
| SCHEMBL1889612 | 0.67 | PARP1 (0.80) | PARP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8080573-B2 | Heterocycle substituted amide and sulfur amide derivatives as histone deacetylase (hdac) inhibitors | ISTITUTO DI RICERCHE DI BIOLOGIA MOLECOLARE P. ANGELETTI SPA (IT) | 2011-12-20 | — | — | US | disclosed |
| US-20090156619-A1 | Heterocycle Substituted Amide and Sulfur Amide Derivatives as Histone Deacetylase (HDAC) Inhibitors | MSD ITALIA S.R.L. (IT) | 2009-06-18 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090156619-A1 | Heterocycle Substituted Amide and Sulfur Amide Derivatives as Histone Deacetylase (HDAC) Inhibitors | HDAC1, HDAC6, HDAC11 | PARP1 959/4885MGAM 4236/4885GAA 705/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.